DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and ap4b1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_002932178.2	Gene:	ap4b1 / 100495149	XenbaseID:	XB-GENE-949306	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	220/790 - (27%)
Similarity:	377/790 - (47%)	Gaps:	115/790 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELKSELNNDK----KEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYA 77
            |||..|:|..    :.:.:..:.|||..||.|.|||::|.::|....|.::..|||||||:..||
Frog    12 ELKRALSNPNIQADRLRYRNVIHKVIRHMTQGVDVSSVFMEMVKASATVDIVQKKLVYLYMCTYA 76

  Fly    78 KSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAA 142
            ..:||:|::|:||..|||.|.||::|.||:|:|..:|:..|.||:.:|:...|:|:..|||:.|.
Frog    77 CQKPDLALLAINTLCKDCSDPNPMVRGLALRSMCNLRMPGIIEYIQQPIHNGLRDKASYVRRVAV 141

  Fly   143 VCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINK 207
            :..:|::.....:..|...:::|..||.|.:|:||.|.:.||.||    ..|:..|.:|....:.
Frog   142 LGCSKMHSQQGDVEVDGVVVNELYSLLRDPDPIVVVNCLRALEEI----LKGEGGVVINKPIAHH 202

  Fly   208 LLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVLMKL-LEML 271
            ||..:.|..:|||..:|..|..|:||.|.|...|...:...|...:.:||:.|.|:.:.| :|..
Frog   203 LLNRMAELDQWGQSEVLGFLLRYNPKTEDELFDILNLLDNFLKSNHTSVVMGATKLFLVLAVEFP 267

  Fly   272 SSDSDFCATLTKKLAPPLVTLLSSE-PEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYV 335
            :...|    :..:|..||:...:|| .|:.:.||.::..|::..|.......|.||..||||.|:
Frog   268 NVQRD----VLGRLKGPLLAASASESKEMCFAALCHVREILRSMPGHFSSHYKKFFCSYNDPHYI 328

  Fly   336 KLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLI 400
            |.:|:||:..|.|..|:..||.||:...|::.|...:.|:.||||.|   :..:|:||..|..|:
Frog   329 KSQKMDILCELVNDENVHNVLEELRICCTDISVQLAQTAIFAIGRIA---KTFSEKCVKILSQLL 390

  Fly   401 QTKVNYVVQEAIVVIKDIFRKYPNKYESIISTL--CENLDTLDEPEARASMVWIIGEYAERIDNA 463
            :....::....|...:|:....|.....:...|  ||.:  :.:.|.:.:::|::|.:.:.|.||
Frog   391 EFNQEHITSAVIQTFRDLVWLCPQCIAKVCLALPGCEEI--IQDNEGKRALIWLLGMHGDVISNA 453

  Fly   464 DELLDSFLEGFQDE-NAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDRGFIY 527
            ..:|:.|::..:.| :..|:::||||||:|||.||::.|:::..::....::..:..:||||..|
Frog   454 PYILEDFVDNIKTEISPTVKIELLTAVVRLFLSRPAECQDMLGRLIYYCIEEEIDMAVRDRGLFY 518

  Fly   528 WRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRGAGVRK 592
            :|||::....||:|:.:.|.         :|||        |.|.:...:|...:|.  ......
Frog   519 YRLLASGVNEAKQVMNSPKS---------DPTL--------SVLENQTDQPINTWVP--AFNTLM 564

  Fly   593 SLPNRAAGSAAGAEQAENAAGSEAMVIPNQESLIGD-LLSMDINAPAMPSAPAATSNVDLLGGGL 656
            .|.:...|.|.       .||||           || .:|.:||..|           ||
Frog   565 PLHDIKHGLAL-------TAGSE-----------GDHHVSEEINLKA-----------DL----- 595

  Fly   657 DILLGGPPAEAAPGGATSLLGDIFGLGGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVF 721
                 |.|.:||.....|           .:::..::.:::||..:......:       |.:..
Frog   596 -----GNPLDAADLTLES-----------NITMTPEVYEMSWLSTDTACECSL-------NWKTG 637

  Fly   722 MDMTLTNKAMQPMTNFAIQLNKNSFGLVPASPMQAAPLPPNQS---IEVSMALGTNGPIQRMEPL 783
            :...:...::..|..|.|..:|.:     |:|.::.....:.|   ..:.:.|.|:.|
Frog   638 VQPDILQTSLHLMNIFTIAKSKTA-----ANPWKSYLYAQDSSGNLFLIELRLFTDAP------- 690

  Fly   784 NNLQVAVKNN 793
             :|.|:||.|
Frog   691 -SLDVSVKQN 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	164/501 (33%)
		HEAT repeat	51..75	CDD:293787	10/23 (43%)
		HEAT repeat	87..114	CDD:293787	14/26 (54%)
		Cnd1	99..269	CDD:289487	55/170 (32%)
		HEAT repeat	121..151	CDD:293787	9/29 (31%)
		HEAT repeat	160..186	CDD:293787	10/25 (40%)
		HEAT repeat	197..229	CDD:293787	10/31 (32%)
		HEAT repeat	393..417	CDD:293787	4/23 (17%)
		HEAT repeat	429..458	CDD:293787	6/30 (20%)
		HEAT repeat	465..495	CDD:293787	12/30 (40%)
		HEAT repeat	506..542	CDD:293787	10/35 (29%)
		Alpha_adaptinC2	703..799	CDD:197886	16/94 (17%)
		B2-adapt-app_C	809..919	CDD:198088
ap4b1	XP_002932178.2	Adaptin_N	11..522	CDD:366724	169/522 (32%)
		HEAT repeat	86..113	CDD:293787	14/26 (54%)
		HEAT repeat	120..150	CDD:293787	9/29 (31%)
		HEAT repeat	159..185	CDD:293787	10/25 (40%)
		B2-adapt-app_C	612..716	CDD:370272	18/108 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920