DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AP-1-2beta and ap3b1

DIOPT Version :9

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:XP_012822818.3 Gene:ap3b1 / 100493180 XenbaseID:XB-GENE-987208 Length:1097 Species:Xenopus tropicalis


Alignment Length:1098 Identity:277/1098 - (25%)
Similarity:461/1098 - (41%) Gaps:238/1098 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 YFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVY 70
            :.|..||.|  :||..|.::|...|.||:|:::..::.||:.|.|||.||..:.:.|||:|||||
 Frog    50 FSTDLKKNE--DLKQMLESNKDSSKLEAMKRIVGMISDGKNASELFPAVVKNVASKNLEIKKLVY 112

  Fly    71 LYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDP 135
            :||:.||:.|.|:|::::.||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..|
 Frog   113 VYLVRYAEEQQDLALLSIATFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAAADLSP 177

  Fly   136 YVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEM 200
            |||||||..:.|||.:...  :....::.::.||.|.:.:|..:.|.|..|:   ......|:..
 Frog   178 YVRKTAAHAIQKLYSLDPE--QKDMLIEVIEKLLKDKSTLVAGSVVMAFEEV---CPDRIDLIHK 237

  Fly   201 NSVTINKLLTALNECTEWGQVFILDSLANY------SP------------------KDEREAQS- 240
            |   ..||...|.:..|||||.|:..|..|      ||                  .:|::|.: 
 Frog   238 N---YRKLCNLLVDVEEWGQVVIIHMLTRYARMQFVSPWVEEGDSGEMTTQSFYESDEEKDADTN 299

  Fly   241 -------------ICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTL 292
                         :.....|.|...|||||::    :.:|...|:..|:     |..:|..|:.|
 Frog   300 QKRPYVMDPDHRLLLRNTKPLLQSRNAAVVMA----VAQLYWHLAPKSE-----TSTVAKSLIRL 355

  Fly   293 LSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLS 357
            |.|..||||:.|:||..|..:|..:.:..:|.|:::..||..:|..||:||..|||::|::.:|.
 Frog   356 LRSHREVQYIVLQNIATISIQRKGLFEPYLKSFYIRSTDPTMIKTLKLEIMTNLANEANVSTLLR 420

  Fly   358 ELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKY 422
            |.:.|....|..|....::||||||..:....:.|::.|:.|:..:.:.||.|::||||.:.:..
 Frog   421 EFQTYVRSQDKQFAAATIQAIGRCATNISAVTDTCLNGLVLLLSNRDDVVVAESVVVIKKLLQTQ 485

  Fly   423 PNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLL 486
            .:.:..||..:.:..|.:..|.||||::|:||||.||:.. |.::|....:.|.:|:..|:||::
 Frog   486 TSHHSDIIRHMAKLFDKITVPMARASILWLIGEYCERVPKIAPDVLRKTAKSFTNEDDLVKLQII 550

  Fly   487 TAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA-----AKEVVLAD 545
            ...|||||.....|:.|.|::|:|...| .|.|:||| .|:...::..:.:.     ||::.||.
 Frog   551 NLAVKLFLTNSKQTKLLAQYILNLGKYD-QNYDIRDRTRFVKQLIVPNEKSGALSKYAKKIFLAQ 614

  Fly   546 KPLISEETDLLEPTLLDELICHISSLA-----------------------SVYHKPPTAFVEGRG 587
            ||     ..:|:.:..|.....:.:|:                       ||.:..|:..|:.:.
 Frog   615 KP-----APVLKSSFKDREHFQLGTLSHSLNTKASGYLELSDWPEIAPDPSVRNVEPSEPVKNKA 674

  Fly   588 -----AGVRKSLPNRAAGSAAGAEQAE-------------------------------------- 609
                 |...||.....:.|..|.:::|                                      
 Frog   675 TKQEMANTEKSSDKFYSDSEEGEKESEESSENESESEEDSDNEKESSSEQSDASSSAESESESDE 739

  Fly   610 -----------------------------------NAAGSEAMVIPNQESLIGDLLSMDI----- 634
                                               .:|.||:.....:||......|..:     
 Frog   740 SSSKEQKNRKKDSEDEKKGTGTKSEDSSVYSEDSSESASSESSSESEEESESEPETSKKVTNSKK 804

  Fly   635 --NAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPG-GATSLLGDIFGLGGATLSVGVQIPKV 696
              |.|.........:.|.||  .||. ...|.|.|.|. .:.|||.|:.||..::.|..:.:...
 Frog   805 TENKPVKQKEIPRKNEVSLL--DLDD-FNMPAAVAKPSILSPSLLSDLEGLSLSSSSPVINVCTP 866

  Fly   697 TWLPAE--------KGKGLEIQGTFSRRN-----GEVFMDMTLTNKAMQPMTNFAIQLNKNSFGL 748
            :::|::        .||||..|..|.|:.     ..|.:.:|..|...:.:.:..|:..|.:.|:
 Frog   867 SFVPSKTHELLHRMSGKGLAAQYHFPRQQCIFGAQMVTVQITFNNTTDKRIEDIHIEEKKMAAGV 931

  Fly   749 VPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVH---GNVLF- 809
            ...:..|...|.|..||.|||.:......|..    :.|:..|.|    .|:..:.   |.:|. 
 Frog   932 KMHAFNQIDYLEPEGSITVSMGIDFCDSTQTA----SFQLCTKEN----QFSVGIQPPPGELLLP 988

  Fly   810 ---------AEDGQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTT-----NNIFTIA 860
                     .|.|:|   ..:|......|.| .:|:...:||.....|:.:..     |||:..|
 Frog   989 VSLSEADFKKEQGKL---TGMNESSATIAVN-AEYSTPQIIGQRFLQAANLGVVASGQNNIYRFA 1049

  Fly   861 KRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAII 918
            .:.|....::.          |.:|||   |...|.|.:.:....:.:::....:.::
 Frog  1050 AKTVHSGSLML----------VTVELK---GGSAAQLIINTEKTVIGSVLLRELKPVL 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:279882 171/536 (32%)
HEAT repeat 51..75 CDD:293787 14/23 (61%)
HEAT repeat 87..114 CDD:293787 10/26 (38%)
Cnd1 99..269 CDD:289487 55/207 (27%)
HEAT repeat 121..151 CDD:293787 12/29 (41%)
HEAT repeat 160..186 CDD:293787 6/25 (24%)
HEAT repeat 197..229 CDD:293787 12/31 (39%)
HEAT repeat 393..417 CDD:293787 8/23 (35%)
HEAT repeat 429..458 CDD:293787 13/28 (46%)
HEAT repeat 465..495 CDD:293787 10/29 (34%)
HEAT repeat 506..542 CDD:293787 11/41 (27%)
Alpha_adaptinC2 703..799 CDD:197886 25/100 (25%)
B2-adapt-app_C 809..919 CDD:198088 22/125 (18%)
ap3b1XP_012822818.3 Adaptin_N 59..594 CDD:396262 179/552 (32%)
HEAT repeat 129..157 CDD:293787 11/27 (41%)
HEAT repeat 163..193 CDD:293787 12/29 (41%)
HEAT repeat 201..226 CDD:293787 6/24 (25%)
AP3B1_C 818..961 CDD:405483 38/145 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323029at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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