Protein Alignment AP-1-2beta and ap3b2

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: XP_031753531.1
• Gene: ap3b2 / 100158619
• XenbaseID: XB-GENE-1013377
• Length: 1175
• Species: Xenopus tropicalis
• Alignment Length: 1165
• Identity: 278/1165 - (23%)
• Similarity: 459/1165 - (39%)
• Gaps: 344/1165 - (29%)

  Fly    17 ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
            :||..|:::|...|.||:|:::|.:..||:.|.|||.||..:...|:|:|||||:||:.||:.|.
 Frog    74 DLKEMLDSNKDSLKLEAMKRIVAMIARGKNTSDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQ 138

  Fly    82 DMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146
            |:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..||||||||..:.
 Frog   139 DLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIP 203

  Fly   147 KLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTA 211
            |||.:.:.. :|| .::.::.||||...:|..:.|.|..|:....      :::......||...
 Frog   204 KLYSLDSDQ-KDQ-LIEVIEKLLSDKTTLVAGSVVMAFEEVCPER------IDLIHKNYRKLCNL 260

  Fly   212 LNECTEWGQVFILDSLANYS------------------------------PKDEREAQS------ 240
            |.:..|||||.|::.|..|:                              .|::.|..|
 Frog   261 LIDVEEWGQVVIINMLTRYARTQFLNPNQNESLLEENPEKAFYGSDDDEGGKEKSEPSSMVKHKP 325

  Fly   241 ---------ICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSE 296
                     :.....|.|...|||||::..::...|.....         ...:|..||.||.|.
 Frog   326 YVMDPDHRLLLRNTKPLLQSRNAAVVMAVAQLYFHLAPKAE---------VGVIAKALVRLLRSH 381

  Fly   297 PEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKE 361
            .|||||.|.|:..:..||..:.:..:|.|:::..||..:|:.||:::..|||::||:.:|.|.:.
 Frog   382 SEVQYVVLHNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNISTILREFQT 446

  Fly   362 YATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKY 426
            |...:|.|||...::||||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|.::
 Frog   447 YIRSMDKDFVAATIQAIGRCATNIGKVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQH 511

  Fly   427 ESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVV 490
            ..||..:.:..|.:..|.||||::|:||||.|.:.. |.::|....:.|.:|...|:||.:....
 Frog   512 SEIIKHMAKLTDNIQVPMARASILWLIGEYCEHVPKIAPDVLRKMAKSFTNEEDIVKLQTINLAA 576

  Fly   491 KLFLKRPSDTQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA-----AKEVVLADKPLI 549
            ||:|..|..|:.|.|:||:||..| .|.|:||| .||...::.|:.:.     ||::.||.||
 Frog   577 KLYLTNPKQTKLLTQYVLNLAKYD-QNYDIRDRTRFIRQLIIPTEKSGALSKHAKKLFLAQKP-- 638

  Fly   550 SEETDLLEPTLLDE------LICHISSLASVYHK-----------PPTAFVEGRGA--------- 588
               ..:||.:..|.      .:.|:.:..:|.::           |....||.:.|
 Frog   639 ---APILESSFKDRDHFQLGSLSHLLNAKAVGYQELPDWPEEAPDPSVRNVEVKDAEEEEDSAPR 700

  Fly   589 -------GVRKSLP------------------------------------------------NRA 598
                   |..|.:|                                                :..
 Frog   701 DGHIGLLGEWKEVPEWTKCPSREKRKEREEKPFYSDSEGESGPTESADSEPESESESESGGNSSG 765

  Fly   599 AGSAAGAEQ-----------------------------------------------------AEN 610
            :||.:|:|:                                                     :|:
 Frog   766 SGSGSGSEEEEESEEEEESEKEEKKKEKKRTPQKEDSDESDQEQKQPIRSKRSSAKTSQKSASED 830

  Fly   611 AAGSE------------------------------------------AMVIPNQESLIGDLLSMD 633
            .:.||                                          |...|.:.||      :|
 Frog   831 GSSSESNESETESSSEEEDEDEDEEDEQRQSDPKKKKTPPATKPTAKASKEPKEMSL------LD 889

  Fly   634 INAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLLGDIFGLGGATLSVGVQIPKV-- 696
            ::..::||||..||...:                    :.||:.|:.||   :|:.....|.|
 Frog   890 LDDFSVPSAPLVTSRSIV--------------------SASLVSDLEGL---SLTDSALTPTVIS 931

  Fly   697 ---------TWLPAEKGKGLEIQGTFSRR-----NGEVFMDMTLTNKAMQPMTNFAIQLNKNSFG 747
                     ..|....|:||.::..|||:     |..|.:.:.::||....:.|..|...|...|
 Frog   932 PAFASDRTFELLHRMTGEGLSMEYIFSRQPFTPDNRMVSVQIQISNKTENEVKNIRISEPKLLSG 996

  Fly   748 LVPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAED 812
            :......:...|||.:|..|.|.:......|..    |.|:.....    :|...:...|
 Frog   997 MRIKEFQETECLPPGESATVIMGIDFCDSTQAA----NFQICTHTR----HFYVSIQPPV----- 1048

  Fly   813 GQLDKRVFLNTWKEIPAANEL---QYTLSGVIGTTDGIASKMTTNNIFTIAKR-----NVE---- 865
            |:|...||:       :.||.   |..|:|:...|:.::.....|:...|.:|     |:.
 Frog  1049 GELMAPVFM-------SENEFKREQSKLTGMNEITERLSLSEKCNSDHAIVQRVTSTANMNRVPC 1106

  Fly   866 GQDMLYQSLKLT---------------NNIWVLLELKLQPGNPEATLSLKSRSVEVANII 910
            |.|..|....||               :...||:.|.|:.|: .|.|::.|..:.:..::
 Frog  1107 GADKEYSDPALTFERPTCLRFAAKTVSSGTLVLVTLTLKDGS-AALLTINSEKMVIGTML 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	173/543 (32%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	7/25 (28%)
		HEAT repeat	197..229	CDD:293787	10/31 (32%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	13/28 (46%)
		HEAT repeat	465..495	CDD:293787	8/29 (28%)
		HEAT repeat	506..542	CDD:293787	15/41 (37%)
		Alpha_adaptinC2	703..799	CDD:197886	23/100 (23%)
		B2-adapt-app_C	809..919	CDD:198088	27/129 (21%)
ap3b2	XP_031753531.1	Adaptin_N	68..620	CDD:396262	180/563 (32%)
		HEAT repeat	144..172	CDD:293787	11/27 (41%)
		HEAT repeat	178..206	CDD:293787	10/27 (37%)
		HEAT repeat	215..241	CDD:293787	8/26 (31%)
		AP3B1_C	881..1027	CDD:464319	39/174 (22%)