DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and ap1b1

DIOPT Version :10

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_001121444.1 Gene:ap1b1 / 100158536 XenbaseID:XB-GENE-984900 Length:946 Species:Xenopus tropicalis


Alignment Length:952 Identity:702/952 - (73%)
Similarity:801/952 - (84%) Gaps:38/952 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
 Frog     1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
 Frog    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.|:..|..
 Frog   131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSN 195

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
             |:::|..:||||||||||||||||:||||.||||.|||:|||||:|||:||||:||||||||||
 Frog   196 -LLDLNPQSINKLLTALNECTEWGQIFILDCLANYIPKDDREAQSVCERVTPRLSHANAAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.:|:||.|.|:..||.||||||||||||:|||:||||||||||||||||:|||||||||
 Frog   260 VKVLMKFMELLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:.:||||||:|||||||||||||||||||||||||||||.|||
 Frog   325 FVKYNDPIYVKLEKLDIMIRLASPANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            ||||||||||||||||||||||||||||||||||||||:|||||||||:||||||||:|:||:||
 Frog   390 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVISTLCENLDSLDEPEARAAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.|||||||||:||||||:|::||||||.||||||||||||||
 Frog   455 YAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||.||||||||:||||||||||:||||||||||:|.:|||||||||.|||||
 Frog   520 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPNAFVEG 584

  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENA-AG----SEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645
            ....|.|.||.| .||:..||..|.| ||    :...|||:|..|:||||::|: ||.:...|..
 Frog   585 SRGVVPKRLPPR-TGSSESAESPEAAPAGVPTETHPSVIPSQGDLLGDLLNLDL-APPITGPPLT 647

  Fly   646 TSN-----VDLLGGGLDILLGG--------------PPAEAAP-----GGATSLLGDIFGLGGAT 686
            ||:     |||||||||.||||              ||..|.|     ||.   |||:|.|||.|
 Frog   648 TSSVPLGGVDLLGGGLDSLLGGDASTGLGLPTGFMAPPVAANPLGQSLGGG---LGDLFDLGGGT 709

  Fly   687 LSV-GVQI-PKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLV 749
            ..| |..: ||..||.|.|||||||.|||:||:|.||||:..||:|:|.|::||||.|:|||||.
 Frog   710 GGVPGPYVAPKAVWLHAMKGKGLEISGTFARRSGTVFMDLVFTNRALQVMSDFAIQFNRNSFGLA 774

  Fly   750 PASPMQ-AAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDG 813
            ||:|:| ..||.||||.|||:.:.|.|.:.:||||||||||||||||:|||:.|...::||.|||
 Frog   775 PAAPLQILTPLAPNQSTEVSLPINTIGSVMKMEPLNNLQVAVKNNIDVFYFSILYPLHILFIEDG 839

  Fly   814 QLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLTN 878
            ::::::||.|||:|...||.|:.:......:|.:::|:..:||||:|:|.||||||||||:||||
 Frog   840 KMERQMFLATWKDIANENEAQFQIRDCPTGSDAVSNKLQASNIFTVARRTVEGQDMLYQSMKLTN 904

  Fly   879 NIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAIIRS 920
            .||||.|:::|||:|..|||||..:.||:..:|.|||.::::
 Frog   905 GIWVLAEVRMQPGSPNCTLSLKCCAPEVSQFVFQAYETVVKN 946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:396262 437/496 (88%)
HEAT repeat 51..75 CDD:293787 23/23 (100%)
HEAT repeat 87..114 CDD:293787 25/26 (96%)
HEAT repeat 121..151 CDD:293787 28/29 (97%)
HEAT repeat 160..186 CDD:293787 23/25 (92%)
HEAT repeat 197..229 CDD:293787 23/31 (74%)
HEAT repeat 393..417 CDD:293787 23/23 (100%)
HEAT repeat 429..458 CDD:293787 23/28 (82%)
HEAT repeat 465..495 CDD:293787 24/29 (83%)
HEAT repeat 506..542 CDD:293787 32/35 (91%)
Alpha_adaptinC2 703..799 CDD:197886 64/96 (67%)
B2-adapt-app_C 809..919 CDD:198088 55/109 (50%)
ap1b1NP_001121444.1 Adaptin_N 11..534 CDD:396262 462/523 (88%)
HEAT repeat 51..75 CDD:293787 23/23 (100%)
HEAT repeat 87..114 CDD:293787 25/26 (96%)
HEAT repeat 121..151 CDD:293787 28/29 (97%)
HEAT repeat 160..186 CDD:293787 23/25 (92%)
HEAT repeat 197..228 CDD:293787 22/30 (73%)
HEAT repeat 355..379 CDD:293787 22/23 (96%)
HEAT repeat 391..419 CDD:293787 27/27 (100%)
HEAT repeat 427..458 CDD:293787 25/30 (83%)
HEAT repeat 464..490 CDD:293787 20/25 (80%)
Alpha_adaptinC2 726..826 CDD:197886 66/99 (67%)
B2-adapt-app_C 835..945 CDD:198088 55/109 (50%)

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