Protein Alignment AP-1-2beta and ap1b1

DIOPT Version :9

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_001121444.1
• Gene: ap1b1 / 100158536
• XenbaseID: XB-GENE-984900
• Length: 946
• Species: Xenopus tropicalis
• Alignment Length: 952
• Identity: 702/952 - (73%)
• Similarity: 801/952 - (84%)
• Gaps: 38/952 - (3%)

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
 Frog     1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
 Frog    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.|:..|..
 Frog   131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSN 195

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
             |:::|..:||||||||||||||||:||||.||||.|||:|||||:|||:||||:||||||||||
 Frog   196 -LLDLNPQSINKLLTALNECTEWGQIFILDCLANYIPKDDREAQSVCERVTPRLSHANAAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.:|:||.|.|:..||.||||||||||||:|||:||||||||||||||||:|||||||||
 Frog   260 VKVLMKFMELLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:.:||||||:|||||||||||||||||||||||||||||.|||
 Frog   325 FVKYNDPIYVKLEKLDIMIRLASPANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            ||||||||||||||||||||||||||||||||||||||:|||||||||:||||||||:|:||:||
 Frog   390 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVISTLCENLDSLDEPEARAAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.|||||||||:||||||:|::||||||.||||||||||||||
 Frog   455 YAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||.||||||||:||||||||||:||||||||||:|.:|||||||||.|||||
 Frog   520 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPNAFVEG 584

  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENA-AG----SEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645
            ....|.|.||.| .||:..||..|.| ||    :...|||:|..|:||||::|: ||.:...|..
 Frog   585 SRGVVPKRLPPR-TGSSESAESPEAAPAGVPTETHPSVIPSQGDLLGDLLNLDL-APPITGPPLT 647

  Fly   646 TSN-----VDLLGGGLDILLGG--------------PPAEAAP-----GGATSLLGDIFGLGGAT 686
            ||:     |||||||||.||||              ||..|.|     ||.   |||:|.|||.|
 Frog   648 TSSVPLGGVDLLGGGLDSLLGGDASTGLGLPTGFMAPPVAANPLGQSLGGG---LGDLFDLGGGT 709

  Fly   687 LSV-GVQI-PKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLV 749
            ..| |..: ||..||.|.|||||||.|||:||:|.||||:..||:|:|.|::||||.|:|||||.
 Frog   710 GGVPGPYVAPKAVWLHAMKGKGLEISGTFARRSGTVFMDLVFTNRALQVMSDFAIQFNRNSFGLA 774

  Fly   750 PASPMQ-AAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDG 813
            ||:|:| ..||.||||.|||:.:.|.|.:.:||||||||||||||||:|||:.|...::||.|||
 Frog   775 PAAPLQILTPLAPNQSTEVSLPINTIGSVMKMEPLNNLQVAVKNNIDVFYFSILYPLHILFIEDG 839

  Fly   814 QLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLTN 878
            ::::::||.|||:|...||.|:.:......:|.:::|:..:||||:|:|.||||||||||:||||
 Frog   840 KMERQMFLATWKDIANENEAQFQIRDCPTGSDAVSNKLQASNIFTVARRTVEGQDMLYQSMKLTN 904

  Fly   879 NIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAIIRS 920
            .||||.|:::|||:|..|||||..:.||:..:|.|||.::::
 Frog   905 GIWVLAEVRMQPGSPNCTLSLKCCAPEVSQFVFQAYETVVKN 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	437/496 (88%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		Cnd1	99..269	CDD:289487	142/169 (84%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	23/28 (82%)
		HEAT repeat	465..495	CDD:293787	24/29 (83%)
		HEAT repeat	506..542	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	703..799	CDD:197886	64/96 (67%)
		B2-adapt-app_C	809..919	CDD:198088	55/109 (50%)
ap1b1	NP_001121444.1	Adaptin_N	11..534	CDD:366724	462/523 (88%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	355..379	CDD:293787	22/23 (96%)
		HEAT repeat	391..419	CDD:293787	27/27 (100%)
		HEAT repeat	427..458	CDD:293787	25/30 (83%)
		HEAT repeat	464..490	CDD:293787	20/25 (80%)
		Alpha_adaptinC2	726..826	CDD:197886	66/99 (67%)
		B2-adapt-app_C	835..945	CDD:198088	55/109 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	902	1.000	Domainoid score	I54
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21972
Inparanoid	1	1.050	1346	1.000	Inparanoid score	I140
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm48254
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090