DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and ap3b2

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_021326282.1	Gene:	ap3b2 / 100000165	-ID:	-	Length:	1091	Species:	Danio rerio

Alignment Length:	985	Identity:	251/985 - (25%)
Similarity:	405/985 - (41%)	Gaps:	280/985 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIM 86
            |:::|...|.||:|:::|.:..||:.|.|||.||..:...|:|:|||||:||:.||:.|.|:|::
Zfish     2 LDSNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALL 66

  Fly    87 AVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDI 151
            :::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..||||||||..:.||:.:
Zfish    67 SISTFQRGLKDPNQLIRASALRVLSSIRVTIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLHSL 131

  Fly   152 SATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTALNECT 216
            .... :|| .::.::.||:|...:|..:.|.|..|:   ......|:..|   ..||...|.:..
Zfish   132 DPDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEV---CPDRIDLIHKN---YRKLCNLLIDVE 188

  Fly   217 EWGQVFILDSLANYS---------------------------PKDE---REAQSICER------- 244
            |||||.|::.|..|:                           .:||   .||.::.:|
Zfish   189 EWGQVVIINMLTRYARTQFLNPNINESLLEEGSEKAFYASDDEEDEDKKAEAAALAKRKPYVMDP 253

  Fly   245 --------ITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQY 301
                    ..|.|...|||||::..::...|.....         ...:|..||.|:.|..||||
Zfish   254 DHRLLLRNTKPLLQSRNAAVVMAVAQLYFHLAPKAE---------VGVIAKALVRLMRSHSEVQY 309

  Fly   302 VALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEV 366
            |.|:|:..:..||..:.:..:|.|:::..||..:|:.||:::..|||::||:.:|.|.:.|...:
Zfish   310 VVLQNVATMTIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNISTILREFQTYIKSM 374

  Fly   367 DVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIIS 431
            |.|||..:::||||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|.::..||.
Zfish   375 DKDFVAASIQAIGRCATNIGEVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPEQHSDIIK 439

  Fly   432 TLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVVKLFLK 495
            .:.:.:|.:..|.||||::|:||||.|.:.. |.::|....:.|.:|...|:||::....||:|.
Zfish   440 HMAKLIDNIQVPMARASILWLIGEYCEHVPKIAPDVLRKMAKTFTNEEDIVKLQIINLAAKLYLT 504

  Fly   496 RPSDTQELVQHVLSLATQDSDNPDLRDRG-FIYWRLLSTDPAA-----AKEVVLADKPLISEETD 554
            ....|:.|.|:||:||..| .|.|:|||. ||...::.||.:.     ||::.||.||     ..
Zfish   505 NSKQTKLLTQYVLNLAKYD-QNYDIRDRARFIRQLIVPTDKSGALSKYAKKLFLALKP-----AP 563

  Fly   555 LLEPTLLDELICHISSL-------ASVYHKPP--------------------------TAFVEGR 586
            :||....|.....:.||       ||.|.:.|                          |:..|..
Zfish   564 VLESPFKDRDHFQLGSLSHLLNAKASGYQELPDWPESAPDPSVRNVEVIRLLERVTTLTSIPEWS 628

  Fly   587 GAGVRK------------------SLPNRAAG----------SAAGAEQAENA-AGSEA------ 616
            ....||                  |.|..:|.          ||:|:|::.:| :|||:
Zfish   629 KCTSRKDRKEKKVEKPFYSDSEGESGPTESADSESDSGSGSESASGSEESRSARSGSESEDSGEE 693

  Fly   617 ------------------------------------------------MVIPNQESLIG------ 627
                                                            .::.||:|:..
Zfish   694 SESEEEEEDEEDQKKKKKRLEKTKARKAVEESAESEQSSGAEDRKRSRKMVKNQKSVSESDSESE 758

  Fly   628 ------------------------------------------------DLLSMDINAPAMPSAPA 644
                                                            .||.:|...||..|||.
Zfish   759 SSESEEESEEESEEESESDTDIRKKKAPVSKPPPKPSKKESKKENKEMSLLDLDDFEPAPASAPV 823

  Fly   645 ATSNV-------DLLGGGL-DILLGGPPAEAAPGGATSLLGDIFGLGGATLSVGVQIPKVTWLPA 701
            ...|.       ||.|..| |.:|.  |...||.|:..:    :.|          :.::|
Zfish   824 TPVNFLSSSLVSDLEGLSLTDTILA--PTTIAPSGSIKM----YEL----------LHRIT---- 868

  Fly   702 EKGKGLEIQGTFSRR-----NGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLVPASPMQAAPLPP 761
              |:||.::..|||:     ...|.:.:..||.......|..|:..:...|:......:...|..
Zfish   869 --GEGLAVEYCFSRQPFSPDPNMVAVQIQFTNNTNAETKNLHIEEPRLQSGMRIREFSEIEVLAA 931

  Fly   762 NQSIEVSMAL 771
            |:|:.|.|.:
Zfish   932 NESVTVVMGI 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	173/543 (32%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..269	CDD:289487	57/214 (27%)
		HEAT repeat	121..151	CDD:293787	11/29 (38%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	12/31 (39%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	13/28 (46%)
		HEAT repeat	465..495	CDD:293787	8/29 (28%)
		HEAT repeat	506..542	CDD:293787	16/41 (39%)
		Alpha_adaptinC2	703..799	CDD:197886	17/74 (23%)
		B2-adapt-app_C	809..919	CDD:198088
ap3b2	XP_021326282.1	Adaptin_N	1..543	CDD:307641	178/558 (32%)
		HEAT repeat	67..94	CDD:293787	10/26 (38%)
		HEAT repeat	101..131	CDD:293787	11/29 (38%)
		HEAT repeat	138..164	CDD:293787	7/26 (27%)
		AP3B1_C	806..948	CDD:317233	38/158 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920