Protein Alignment CG12531 and SLC7A1

DIOPT Version :10

• Sequence 1: NP_608350.2
• Gene: CG12531 / 32986
• FlyBaseID: FBgn0031064
• Length: 812
• Species: Drosophila melanogaster
• Sequence 2: NP_003036.1
• Gene: SLC7A1 / 6541
• HGNCID: 11057
• Length: 629
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 263/696 - (37%)
• Similarity: 374/696 - (53%)
• Gaps: 128/696 - (18%)

  Fly    31 KLIRTKDVKQLQDGNAQPQKPKLTKCLNTLDLTSLGIGSCCGTGMYLVAGMVAQKIAGPGVIISF 95
            :::|.|.|      :...::.:|::||||.||.:||:||..|.|:|::||.||::.|||.::|||
Human    12 QMLRRKVV------DCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISF 70

  Fly    96 IIAAIASIFSGACYAEFGVRVPHTSGSAYMYSYVAVGEFVAFIIGWNMILEYLIGTSACACALSS 160
            :|||:||:.:|.||.|||.|||.| ||||:||||.|||..|||.|||:||.|:||||:.|.|.|:
Human    71 LIAALASVLAGLCYGEFGARVPKT-GSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSA 134

  Fly   161 SFDSLTGNAI---ART-ISESIGTIFGKPPDFIAFGITLLMTCVLAMGASKSVIFNHSLNAVNLA 221
            :||.|.|..|   :|| ::.:...:..:.||..|..|.|::|.:|.:|..:|.:.|.....:|:.
Human   135 TFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVL 199

  Fly   222 TWVFVMAAGLFYVDTKTWSEHQ------------------------GFLPYGWSGVFSGAATCFY 262
            ...|:|.:|......|.|...:                        ||:|:|:|||.||||||||
Human   200 VLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFY 264

  Fly   263 AFIGFDIIATTGEEAHNPQKSIPKAIVGSLVVVLIAYVSVSLVLTLVVPYDHINTGAALVQMWSY 327
            ||:|||.|||||||..||||:||..||.||::..|||..||..|||::||..::..:.|...:.:
Human   265 AFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKH 329

  Fly   328 VNAPKCRAVVAIGATAGLSVAMFGSMFPMPRVIYAMAQDGLIFRQLSQLWHRTNVPGLATIGSGL 392
            |.....:..||:|:...||.::.||||||||||||||:|||:|:.|:.:..||..|.:||:.||.
Human   330 VGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGA 394

  Fly   393 AAALVALTVRLEILVEMMSIGTLLAYTLVSTCVLVLRYQPHSTSLVELLPAQLRTPVAHGTASDS 457
            .||::|....|:.||::|||||||||:||:.|||||||||...:||            :..||.|
Human   395 VAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLV------------YQMASTS 447

  Fly   458 RSHVTPAEVLEVPGKLTIKRVTRGMSDSDDSFIDDSPEGFLGGRDDQFLVSDRSENKFYGSVHGA 522
             ..:.||:..|:                  :..:||..|||
Human   448 -DELDPADQNEL------------------ASTNDSQLGFL------------------------ 469

  Fly   523 PTGPTGQATAFDAMGL----NFVTRKIHDYAYLCPGFFPWINPGQATAESGMYVTKLVGIMFGLI 583
                 .:|..|....:    |....||                      ||:.|.....::..||
Human   470 -----PEAEMFSLKTILSPKNMEPSKI----------------------SGLIVNISTSLIAVLI 507

  Fly   584 FFLDLFAAIG----WSGGL-AAFIYFILFIGIFVILLIISRQPQNRYALAFLTPGLPFIPAIAIT 643
            ....:...:|    ..|.| |.|:.....:...|:..:|.|||:::..|:|..|.||.:|.::|.
Human   508 ITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIF 572

  Fly   644 VNIYLIFKLSILTLVRFTVWMSLGFIMYFYYGITHSSLEQASDDLE 689
            ||:||:.:|...|.|||.|||.:|||:||.||:.||  |:||.|.:
Human   573 VNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHS--EEASLDAD 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12531	NP_608350.2	2A0303	52..679	CDD:273330	254/663 (38%)
SLC7A1	NP_003036.1	2A0303	4..610	CDD:273330	259/688 (38%)