DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14232 and ACBD3

DIOPT Version :9

Sequence 1:	NP_001245766.1	Gene:	CG14232 / 32983	FlyBaseID:	FBgn0031061	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_073572.2	Gene:	ACBD3 / 64746	HGNCID:	15453	Length:	528	Species:	Homo sapiens

Alignment Length:	511	Identity:	207/511 - (40%)
Similarity:	287/511 - (56%)	Gaps:	62/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SGTSGTSSSETAQSTDMAPSSA--------EKWGFPLIELYRLAFTFYKRNSGKAIHLSYEDNLK 59
            ||....:|.|..:..:.|...|        ::|||.|.|||.||..|:|...|||.|.:||:.||
Human    47 SGRGPGASGEQPEPGEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLK 111

  Fly    60 LIAFKQQAALGPFNTSRAPALGVLDVIGRDRQQHWQLLGEITREQAMEGFVDLLDTMCSAFRPYI 124
            |:|..:|..:||:|....|.:|..||:|.||::.|..||.:::|.||..||.||:..|..|..|:
Human   112 LVALHKQVLMGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYV 176

  Fly   125 ----------------EAVRQDRDETLRKELRLMEEKKEARE-----RQENAQQELLEEGYKEEL 168
                            |..|:.|:|..|:.|:..|||:...|     |:|..::.:.||..:.|.
Human   177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241

  Fly   169 QRRQLQDALNKQTYQQFKLYAEKQFPGNPEQQAVLIHQLQREHYHQYMQQLHLQNQNQNQNQNTE 233
            |::|:..|||.||..||:.||.:|:|||.|||.:||.|||.:||.||||||:   |.|...|...
Human   242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY---QVQLAQQQAA 303

  Fly   234 DKGHQE----AEHVPGNNNNSSTDLPNAMEGLKLGEVETQQHQQLAEQQDGHVEQTLEGVGQEQH 294
            .:..||    ...:|.::..::| :|:.|..:. |:.:|.......|.:....|:.||      :
Human   304 LQKQQEVVVAGSSLPTSSKVNAT-VPSNMMSVN-GQAKTHTDSSEKELEPEAAEEALE------N 360

  Fly   295 GEEEYDDYVMICPAKIWTRPDIEQFKTEVSAGDGDGVITIGHGDTVTVRVPTNMNGKCIFWEFAT 359
            |.:|  ...:|....:||||.|:.||.::.. |.|.|||:|.|:.|||||||:..|..:||||||
Human   361 GPKE--SLPVIAAPSMWTRPQIKDFKEKIQQ-DADSVITVGRGEVVTVRVPTHEEGSYLFWEFAT 422

  Fly   360 DSYDIGFGIYFEWAKPVTNEVTVHVSDSDEDEDCVDEDYLSTTEDLESGSLSQERGAVNNPTAAP 424
            |:||||||:||||.......|:||||:|.:|    ||:        |..::..|..|..|   |.
Human   423 DNYDIGFGVYFEWTDSPNTAVSVHVSESSDD----DEE--------EEENIGCEEKAKKN---AN 472

  Fly   425 KAPISIIVPIYRRECYNEVYVGSHSYPGEGVYLLKFDNSYSIWRNKTLYYRVYYER 480
            |..:..|||:|||:|:.|||.|||.|||.||||||||||||:||:|::||||||.|
Human   473 KPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14232	NP_001245766.1	ACBP	33..117	CDD:279259	38/83 (46%)
CG14232	NP_001245766.1	GOLD_2	334..478	CDD:290608	77/143 (54%)
ACBD3	NP_073572.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		6/23 (26%)
		ACBP	84..170	CDD:395715	38/85 (45%)
		Charged amino-acid region (CAR). /evidence=ECO:0000269\|PubMed:23572552	182..240		14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..230		12/47 (26%)
		Q domain, Interaction with PI4KB, TBC1D22A and TBC1D22B. /evidence=ECO:0000269\|PubMed:23572552, ECO:0000269\|PubMed:27009356	241..308		34/69 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..362		6/33 (18%)
		GOLD_2	397..527	CDD:404736	78/144 (54%)
		Membrane-binding. /evidence=ECO:0000269\|PubMed:28065508, ECO:0000269\|PubMed:31381608	514..516		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151432
Domainoid	1	1.000	163	1.000	Domainoid score	I3969
eggNOG	1	0.900	-	-		E1_KOG3878
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2262
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45273
OrthoDB	1	1.010	-	-		D321733at33208
OrthoFinder	1	1.000	-	-		FOG0006065
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105136
Panther	1	1.100	-	-	LDO	PTHR22973
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3966
SonicParanoid	1	1.000	-	-		X4360
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800