DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14232 and acbd3

DIOPT Version :9

Sequence 1:	NP_001245766.1	Gene:	CG14232 / 32983	FlyBaseID:	FBgn0031061	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001315136.1	Gene:	acbd3 / 406270	ZFINID:	ZDB-GENE-040426-1930	Length:	523	Species:	Danio rerio

Alignment Length:	515	Identity:	205/515 - (39%)
Similarity:	282/515 - (54%)	Gaps:	72/515 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GTSGTSSSET-AQSTD---MAPSSA----EKWGFPLIELYRLAFTFYKRNSGKAIHLSYEDNLKL 60
            |.|...|.|. .||.|   ..|:|:    .||||.|:|||.||..|:|...|||.|.:|:|.|:|
Zfish    43 GQSAEQSHENPEQSVDGEEGEPTSSANIERKWGFALVELYGLALRFFKEKDGKAFHPTYKDKLRL 107

  Fly    61 IAFKQQAALGPFNTSRAPALGVLDVIGRDRQQHWQLLGEITREQAMEGFVDLLDTMCSAFRPYI- 124
            :|..:|...||:|...:|.:|..||:|.||::.|..||.:.:|::|..||.||:..|:.|.|::
Zfish   108 VALHKQVLQGPYNPDASPEVGFFDVLGNDRRKEWASLGNMEKEESMLEFVRLLNKCCNLFAPFVA 172

  Fly   125 ---------EAVRQDRDETLRKE------LRLMEEKKEARE-----RQENAQQELLEEGYKEELQ 169
                     |..|::.:|..|:|      ||..||::...|     |:|..::::.||..:.|.|
Zfish   173 SHKIEKEEQERKRREEEEQRRREEEEYERLRQEEERRRREEEERLRREEEERRQIEEERLRIEQQ 237

  Fly   170 RRQLQDALNKQTYQQFKLYAEKQFPGNPEQQAVLIHQLQREHYHQYMQQLHLQNQNQNQNQNTED 234
            ::|:..|||.||..||:.||.:|:|.:||||.:||.|||.:||.||||||:   |.|...|....
Zfish   238 KQQIMAALNAQTAIQFQQYAAQQYPDSPEQQLILIRQLQEQHYQQYMQQLY---QVQLAQQQAAL 299

  Fly   235 KGHQEAEHVPGNNNNSSTDLPNAMEGLKLGEVETQQHQQLAEQQDGHVEQTLEGVGQEQHGE--E 297
            :..||...|......|....|...|...|               :|..|.|.:.:.::|..|  :
Zfish   300 QKQQEDAIVLSTLEASEVSAPCGEEVPTL---------------NGQAESTTDSIERDQDLEPAD 349

  Fly   298 EY------DDYVMICPAKIWTRPDIEQFKTEVSAGDGDGVITIGHGDTVTVRVPTNMNGKCIFWE 356
            |.      |...:|....:||||.|:.||.::.. |.|.|||:|.|:.|||||||:..|..:|||
Zfish   350 EVTENGPTDSPPVIAAPSMWTRPQIKDFKVKIRQ-DVDSVITVGRGEVVTVRVPTHEEGSYLFWE 413

  Fly   357 FATDSYDIGFGIYFEWAKPVTNEVTVHVSD-SDEDEDCVDEDYLSTTEDLESGSLSQERGAVNNP 420
            ||||.||||||::|||.......|:||||: |||:|:             |.|....|.......
Zfish   414 FATDYYDIGFGVFFEWTDSTNASVSVHVSESSDEEEE-------------EEGEAQSEEEKAKKE 465

  Fly   421 TAAPKAPISIIVPIYRRECYNEVYVGSHSYPGEGVYLLKFDNSYSIWRNKTLYYRVYYER 480
            :..|:  :..|||:|||:|:.|||.|||.|||.|:||||||||||:||:||:||||||.|
Zfish   466 SGKPQ--VDEIVPVYRRDCHEEVYAGSHQYPGRGIYLLKFDNSYSLWRSKTVYYRVYYTR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14232	NP_001245766.1	ACBP	33..117	CDD:279259	36/83 (43%)
CG14232	NP_001245766.1	GOLD_2	334..478	CDD:290608	74/144 (51%)
acbd3	NP_001315136.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585912
Domainoid	1	1.000	163	1.000	Domainoid score	I3919
eggNOG	1	0.900	-	-		E1_KOG3878
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2289
OMA	1	1.010	-	-		QHG45273
OrthoDB	1	1.010	-	-		D321733at33208
OrthoFinder	1	1.000	-	-		FOG0006065
OrthoInspector	1	1.000	-	-		otm25983
orthoMCL	1	0.900	-	-		OOG6_105136
Panther	1	1.100	-	-	LDO	PTHR22973
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3966
SonicParanoid	1	1.000	-	-		X4360
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.890