DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14232 and Acbd3

DIOPT Version :9

Sequence 1:	NP_001245766.1	Gene:	CG14232 / 32983	FlyBaseID:	FBgn0031061	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_878263.1	Gene:	Acbd3 / 289312	RGDID:	727851	Length:	526	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	208/509 - (40%)
Similarity:	285/509 - (55%)	Gaps:	57/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASGTSGTSSSETAQSTDMAPSSAEK----WGFPLIELYRLAFTFYKRNSGKAIHLSYEDNLKLI 61
            :.|||:|........:.:.|...|.:    |||.|.|||.||..|||...|||.|.:||:.||.:
  Rat    46 LGSGTAGQQREPGEAAAEGAAEEARRMEQHWGFGLEELYGLALRFYKIKDGKAFHPTYEEKLKFV 110

  Fly    62 AFKQQAALGPFNTSRAPALGVLDVIGRDRQQHWQLLGEITREQAMEGFVDLLDTMCSAFRPYI-- 124
            |..:|..|||:|...:|.:|..||:|.||::.|..||.:::|.||..||.||:..|.....|:
  Rat   111 ALHKQVLLGPYNPDTSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNKCCPLLSAYVAS 175

  Fly   125 --------------EAVRQDRDETLRKELRLMEEKKEARE-----RQENAQQELLEEGYKEELQR 170
                          |..|:.|:|..|:.|:..|||::..|     |:|..::.:.||..:.|.|:
  Rat   176 HRIEKEEEEKRRKAEEERRQREEEERERLQKEEEKRKREEEDRLRREEEERRRIEEERLRLEQQK 240

  Fly   171 RQLQDALNKQTYQQFKLYAEKQFPGNPEQQAVLIHQLQREHYHQYMQQLHLQNQNQNQNQNTEDK 235
            :|:..|||.||..||:.||.:|:|||.|||.:||.|||.:||.||||||:   |.|...|....:
  Rat   241 QQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY---QVQLAQQQAALQ 302

  Fly   236 GHQEAEHVPGNNNNSSTDLPNAMEGLKL---GEVETQQHQQLAEQQDGHVEQTLEGVGQEQHGEE 297
            ..||.. |.|.:..:||.:..|.....|   |:.:|  |.:       :.|:.||....|:..|.
  Rat   303 KQQEVV-VAGASLPASTKVNTAGASDPLPVNGQAKT--HTE-------NPEKVLEPEAAEEALEN 357

  Fly   298 -EYDDYVMICPAKIWTRPDIEQFKTEVSAGDGDGVITIGHGDTVTVRVPTNMNGKCIFWEFATDS 361
             ..|...:|....:||||.|:.||.::.. |.|.|||:..|:.|||||||:..|..:||||||||
  Rat   358 GPKDSLPVIAAPSMWTRPQIKDFKEKIRQ-DADSVITVRRGEVVTVRVPTHEEGSYLFWEFATDS 421

  Fly   362 YDIGFGIYFEWAKPVTNEVTVHVSDSDEDEDCVDEDYLSTTEDLESGSLSQERGAVNNPTAAPKA 426
            ||||||:||||.......|:||||:|.:||:..:|:.::..|..:..        ||.|.
  Rat   422 YDIGFGVYFEWTDSPNAAVSVHVSESSDDEEEEEEENVTCEEKAKKN--------VNKPL----- 473

  Fly   427 PISIIVPIYRRECYNEVYVGSHSYPGEGVYLLKFDNSYSIWRNKTLYYRVYYER 480
             :..|||:|||:|:.|||.|||.|||.||||||||||||:||:|::||||||.|
  Rat   474 -LDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14232	NP_001245766.1	ACBP	33..117	CDD:279259	39/83 (47%)
CG14232	NP_001245766.1	GOLD_2	334..478	CDD:290608	75/143 (52%)
Acbd3	NP_878263.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..68		5/21 (24%)
		ACBP	81..167	CDD:279259	39/85 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..226		12/45 (27%)
		Interaction with PI4KB. /evidence=ECO:0000250\|UniProtKB:Q9H3P7	238..305		34/69 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..343		6/33 (18%)
		GOLD_2	394..525	CDD:290608	76/144 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344926
Domainoid	1	1.000	164	1.000	Domainoid score	I3848
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2189
OMA	1	1.010	-	-		QHG45273
OrthoDB	1	1.010	-	-		D321733at33208
OrthoFinder	1	1.000	-	-		FOG0006065
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105136
Panther	1	1.100	-	-	LDO	PTHR22973
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4360
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910