DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14231 and OSGEPL1

DIOPT Version :9

Sequence 1:	NP_001245765.1	Gene:	CG14231 / 32982	FlyBaseID:	FBgn0031060	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_024308807.1	Gene:	OSGEPL1 / 64172	HGNCID:	23075	Length:	425	Species:	Homo sapiens

Alignment Length:	371	Identity:	156/371 - (42%)
Similarity:	216/371 - (58%)	Gaps:	15/371 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VLGIETSCDDTGIAIVDTTGRVIANVLESQQEFHTRYGGIIPPRAQDLHRARIESAYQRCMEAAQ 91
            |||||||||||..|:||.||.|:...:.||.|.|.:.|||:||.||.|||..|:...|..:.|:.
Human    50 VLGIETSCDDTAAAVVDETGNVLGEAIHSQTEVHLKTGGIVPPAAQQLHRENIQRIVQEALSASG 114

  Fly    92 LKPDQLTAIAVTTRPGLPLSLLVGVRFARHLARRLQKPLLPVHHMEAHALQARMEHPEQIGYPFL 156
            :.|..|:|||.|.:|||.|||.||:.|:..|..:|:||.:|:||||||||..|:.:  ::.:|||
Human   115 VSPSDLSAIATTIKPGLALSLGVGLSFSLQLVGQLKKPFIPIHHMEAHALTIRLTN--KVEFPFL 177

  Fly   157 CLLASGGHCQLVVANGPGRLTLLGQTLDDAPGEAFDKIGRRLRLHILPEYRLWNGGRAIEHAAQL 221
            .||.|||||.|.:..|.....|||::||.|||:..||:.|||.|...||....:||:||||.|:
Human   178 VLLISGGHCLLALVQGVSDFLLLGKSLDIAPGDMLDKVARRLSLIKHPECSTMSGGKAIEHLAK- 241

  Fly   222 ASDPLAYEFPLPLAQQRNCNFSFAGIKNNSFRAIRARERAERTPPDGVISNYGDFCAGLLRSVSR 286
            ..:...::...||...:||:|||.|:::.:.:.|..:|:.|......::|:..|..|.:..:::.
Human   242 QGNRFHFDIKPPLHHAKNCDFSFTGLQHVTDKIIMKKEKEEGIEKGQILSSAADIAATVQHTMAC 306

  Fly   287 HLMHRTQRAIEYCLLPHRQLFGDTPPTLVMSGGVANNDAIYANIEHLAAQYGCRSFRPSKRYCSD 351
            ||:.||.|||.:|  ..|.|.......||.|||||:|..|...:|.|.....|....|..|.|:|
Human   307 HLVKRTHRAILFC--KQRDLLPQNNAVLVASGGVASNFYIRRALEILTNATQCTLLCPPPRLCTD 369

  Fly   352 NGVMIAWHGVEQL------LQDKEASTRYDYD---SIDIQGSAGFA 388
            ||:||||:|:|:|      |.|.| ..||:..   .:||....|.|
Human   370 NGIMIAWNGIERLRAGLGILHDIE-GIRYEPKCPLGVDISKEVGEA 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14231	NP_001245765.1	T6A_TsaD_YgjD	27..365	CDD:274748	147/343 (43%)
CG14231	NP_001245765.1	Carbam_trans_N	27..>156	CDD:304575	64/128 (50%)
OSGEPL1	XP_024308807.1	TsaD	49..388	CDD:223607	147/342 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146877
Domainoid	1	1.000	236	1.000	Domainoid score	I2363
eggNOG	1	0.900	-	-		E1_COG0533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5561
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2968
Isobase	1	0.950	-	0	Normalized mean entropy	S2552
OMA	1	1.010	-	-		QHG62482
OrthoDB	1	1.010	-	-		D437484at33208
OrthoFinder	1	1.000	-	-		FOG0003715
OrthoInspector	1	1.000	-	-		oto88458
orthoMCL	1	0.900	-	-		OOG6_100288
Panther	1	1.100	-	-	LDO	PTHR11735
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720