DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc42 and CDC42

DIOPT Version :9

Sequence 1:	NP_001245762.1	Gene:	Cdc42 / 32981	FlyBaseID:	FBgn0010341	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_013330.1	Gene:	CDC42 / 850930	SGDID:	S000004219	Length:	191	Species:	Saccharomyces cerevisiae

Alignment Length:	191	Identity:	151/191 - (79%)
Similarity:	168/191 - (87%)	Gaps:	0/191 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYD 65
            |||:||||||||||||||||||||||:||::||||||||||||||||.|||||||||||||||||
Yeast     1 MQTLKCVVVGDGAVGKTCLLISYTTNQFPADYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYD 65

  Fly    66 RLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDENSTLEKLA 130
            ||||||||.||||||||||:||.|||||||||.||:.|||...|.|:|||||||||:...:|||.
Yeast    66 RLRPLSYPSTDVFLVCFSVISPPSFENVKEKWFPEVHHHCPGVPCLVVGTQIDLRDDKVIIEKLQ 130

  Fly   131 KNKQKPITMEQGEKLAKELKAVKYVECSALTQKGLKNVFDEAILAALEPPEPTKKRKCKFL 191
            :.:.:|||.|||.:||:|||||||||||||||:||||||||||:||||||...|.:||..|
Yeast   131 RQRLRPITSEQGSRLARELKAVKYVECSALTQRGLKNVFDEAIVAALEPPVIKKSKKCAIL 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc42	NP_001245762.1	Cdc42	3..177	CDD:206664	140/173 (81%)
Cdc42	NP_001245762.1	RHO	6..179	CDD:197554	140/172 (81%)
CDC42	NP_013330.1	Cdc42	3..177	CDD:206664	140/173 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341933
Domainoid	1	1.000	293	1.000	Domainoid score	I230
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123986
Inparanoid	1	1.050	317	1.000	Inparanoid score	I460
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000070
OrthoInspector	1	1.000	-	-		oto100094
orthoMCL	1	0.900	-	-		OOG6_104797
Panther	1	1.100	-	-	LDO	PTHR24072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R181
SonicParanoid	1	1.000	-	-		X103
TreeFam	1	0.960	-	-
	14	13.780