DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc42 and RAC2

DIOPT Version :9

Sequence 1:	NP_001245762.1	Gene:	Cdc42 / 32981	FlyBaseID:	FBgn0010341	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_002863.1	Gene:	RAC2 / 5880	HGNCID:	9802	Length:	192	Species:	Homo sapiens

Alignment Length:	193	Identity:	134/193 - (69%)
Similarity:	157/193 - (81%)	Gaps:	3/193 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYD 65
            ||.|||||||||||||||||||||||.||.||:|||||||:..||:..:|..|||:|||||||||
Human     1 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYD 65

  Fly    66 RLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDENSTLEKLA 130
            ||||||||||||||:|||:|||:|:|||:.||.||:.|||..||.:||||::||||:..|:|||.
Human    66 RLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLK 130

  Fly   131 KNKQKPITMEQGEKLAKELKAVKYVECSALTQKGLKNVFDEAILAALEPPEPTK--KRKCKFL 191
            :.|..|||..||..||||:.:|||:|||||||:|||.||||||.|.| .|:||:  ||.|..|
Human   131 EKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVL-CPQPTRQQKRACSLL 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc42	NP_001245762.1	Cdc42	3..177	CDD:206664	124/173 (72%)
Cdc42	NP_001245762.1	RHO	6..179	CDD:197554	123/172 (72%)
RAC2	NP_002863.1	Rac1_like	3..176	CDD:206663	123/172 (72%)
RAC2	NP_002863.1	Effector region. /evidence=ECO:0000255	32..40		6/7 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091615at2759
OrthoFinder	1	1.000	-	-		FOG0000070
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X103
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820