Protein Alignment Cdc42 and RHOH

DIOPT Version :9

• Sequence 1: NP_001245762.1
• Gene: Cdc42 / 32981
• FlyBaseID: FBgn0010341
• Length: 191
• Species: Drosophila melanogaster
• Sequence 2: NP_001265288.1
• Gene: RHOH / 399
• HGNCID: 686
• Length: 191
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 79/195 - (40%)
• Similarity: 122/195 - (62%)
• Gaps: 13/195 - (6%)

  Fly     1 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYD 65
            :.:||||:|||.|||||.||:.:|:..||..|.|||::|..|.|.:.|...:|||:||||.:.:.
Human     2 LSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFR 66

  Fly    66 RLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDENSTLEKLA 130
            .:|||||.|.||.|:|:||.:.:||.|:|.||:.||..:...||.|:|.||.|.|:       :.
Human    67 SIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQRE-------MG 124

  Fly   131 KNKQKPITMEQGEKLAKELKAVKYVECSALTQKGLKNVFDEAILAALEPPEPTKKRK------CK 189
            .::...:...:|:|||::::|..|:|||||:.:|::.||:.|:..|:.......:|:      ||
Human   125 PHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRLFSINECK 189

  Fly   190  189
            Human   190  189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc42	NP_001245762.1	Cdc42	3..177	CDD:206664	75/173 (43%)
		RHO	6..179	CDD:197554	74/172 (43%)
RHOH	NP_001265288.1	Rho	5..169	CDD:206641	75/170 (44%)
		Effector region. /evidence=ECO:0000250	33..41		4/7 (57%)
		Interaction with ZAP70. /evidence=ECO:0000250	73..86		7/12 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091615at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820