DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc42 and RND1

DIOPT Version :9

Sequence 1:	NP_001245762.1	Gene:	Cdc42 / 32981	FlyBaseID:	FBgn0010341	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_055285.1	Gene:	RND1 / 27289	HGNCID:	18314	Length:	232	Species:	Homo sapiens

Alignment Length:	183	Identity:	72/183 - (39%)
Similarity:	106/183 - (57%)	Gaps:	1/183 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRP 69
            |.|:|||...|||.:|.....:.:|..||||||:||...:....:...|.|:||:|...||.:||
Human    15 KLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRP 79

  Fly    70 LSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDENSTLEKLAKNKQ 134
            |.|..:|..|:||.:..|.:.::..:||..||..:|..|..||:|.:.|||.:.|||.:|:..||
Human    80 LCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQ 144

  Fly   135 KPITMEQGEKLAKELKAVKYVECSALT-QKGLKNVFDEAILAALEPPEPTKKR 186
            .||:.|||..:||:|.|..|:|.||.| :|.:.::|..|.:..|..|.|..::
Human   145 APISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQK 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc42	NP_001245762.1	Cdc42	3..177	CDD:206664	69/172 (40%)
Cdc42	NP_001245762.1	RHO	6..179	CDD:197554	69/173 (40%)
RND1	NP_055285.1	Rnd1_Rho6	1..232	CDD:206737	72/183 (39%)
RND1	NP_055285.1	Effector region. /evidence=ECO:0000255	42..50		6/7 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810