DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc42 and RHOBTB2

DIOPT Version :9

Sequence 1:	NP_001245762.1	Gene:	Cdc42 / 32981	FlyBaseID:	FBgn0010341	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_001153508.1	Gene:	RHOBTB2 / 23221	HGNCID:	18756	Length:	749	Species:	Homo sapiens

Alignment Length:	202	Identity:	79/202 - (39%)
Similarity:	117/202 - (57%)	Gaps:	30/202 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEY------VPTVF--DNYAVTV--------MIGGE 49
            ::|||||||||.|||||.|:.:...|...::|      ||||:  |.|.|..        ::...
Human    34 VETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDV 98

  Fly    50 PYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVG 114
            ..:|.|:||.|  |:.:.|..:|.::||.::|||:.:|:|..:||..|.|||.|.|.:.|.:|||
Human    99 SVSLRLWDTFG--DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVG 161

  Fly   115 TQIDLRDENSTLEKLAKNKQ------KP---ITMEQGEKLAKELKAVKYVECSALTQKGLKNVFD 170
            .|:|||  .:.||.:.:.::      ||   :..|:|.::|||| .:.|.|.|.:.|.|:|:|||
Human   162 CQLDLR--YADLEAVNRARRPLARPIKPNEILPPEKGREVAKEL-GIPYYETSVVAQFGIKDVFD 223

  Fly   171 EAILAAL 177
            .||.|||
Human   224 NAIRAAL 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc42	NP_001245762.1	Cdc42	3..177	CDD:206664	77/198 (39%)
Cdc42	NP_001245762.1	RHO	6..179	CDD:197554	76/197 (39%)
RHOBTB2	NP_001153508.1	RhoBTB	35..229	CDD:133275	76/198 (38%)
		RHO	39..230	CDD:197554	74/195 (38%)
		BTB	280..>327	CDD:295341
		BTB	<443..492	CDD:197585
		BTB	<443..490	CDD:295341
		BTB	513..615	CDD:279045
		BTB	523..615	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810