DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSF2 and Hsf

DIOPT Version :9

Sequence 1:NP_004497.1 Gene:HSF2 / 3298 HGNCID:5225 Length:536 Species:Homo sapiens
Sequence 2:NP_001036555.1 Gene:Hsf / 37068 FlyBaseID:FBgn0001222 Length:733 Species:Drosophila melanogaster


Alignment Length:697 Identity:176/697 - (25%)
Similarity:298/697 - (42%) Gaps:237/697 - (34%)


- Green bases have known domain annotations that are detailed below.


Human     5 SNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMASFVRQLNMYG 69
            |.|||||:|||.||::..||..|.|:::||||::.::.:||||:||..:||||||||:|||||||
  Fly    44 SGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYG 108

Human    70 FRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK--IRQEDLTKIISS 132
            |.|:..||:|.::.:|| .:||.||:||:....||:.||||:|::|..::|  ::.|.::||::.
  Fly   109 FHKITSIDNGGLRFDRD-EIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTD 172

Human   133 AQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVS-LKR 196
            .:.::.:|:.::||.|.:|.|||.||:|::.||.|||:|||::.|::||::|:||.::.:| :||
  Fly   173 VKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKR 237

Human   197 ----------------------------------------------------------------- 196
                                                                             
  Fly   238 HVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSPPA 302

Human   197 -KRP--------------------LLLNTNGAQKKNLF-----------------QH---IVKEP 220
             :||                    |||..||....|:.                 ||   .|.|.
  Fly   303 VERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHDVYTVTEA 367

Human   221 TDNHHHKVPHS---------------RTEGLKPRERISD---------DIII--YDVTDDNAD-- 257
            .|:|..:||:|               |.:..:.|:::.:         |:|:  .|:..|::.  
  Fly   368 PDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDILVDSSSPK 432

Human   258 EENIPVIPETNEDVI-------SDPSNCSQYPDIV-------------------IVED----DNE 292
            .:...:...|..||:       |:|.|.|...|::                   |.||    |..
  Fly   433 AQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFISEDMPTDIFEDALLPDGV 497

Human   293 DEYAPVIQSGEQNEPARESLSSGSDGSS---PLMSSAVQL------------------------- 329
            :|.|.:.|   |.:..:.::|||...|:   |..|:.:..                         
  Fly   498 EEAAKLDQ---QQKFGQSTVSSGKFASNFDVPTNSTLLDANQASTSKAAAKAQASEEEGMAVAKY 559

Human   330 ----NGSSSLTSEDPVTMMDSILNDNINLLG--------------KVELLDYLDSIDCSLEDFQA 376
                ||::..|:...:..|.|:|.|..|...              ..||..:|:|:...||..:.
  Fly   560 SGAENGNNRDTNNSQLLRMASVLVDQKNTNSSRISHNQAANSYCCSDELHGHLESMQDELETLKD 624

Human   377 MLSGRQFSIDPDLLVDLF--TSSVQMNPTD------YINNTKSENKGLETTKNNVVQPVSEEGRK 433
            :|.|...:||.::|:...  |.:.|: |.|      :.::...:|.||....:::       ..:
  Fly   625 LLRGDGVAIDQNMLMGALSRTPNFQL-PEDELLLKLFNDSDLMDNYGLSFPNDSI-------SSE 681

Human   434 SKSKPDKQLIQY-TAFPLLAFLDGNPASSVEQAS---TTASSEVLSS 476
            .|:....:||.| ..:.|...||.:..::.::||   ....|.||::
  Fly   682 KKAPSGSELISYQPMYDLSDILDTDDGNNDQEASRRQMQTQSSVLNT 728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSF2NP_004497.1 HSF 6..110 CDD:214654 56/103 (54%)
Nuclear localization signal. /evidence=ECO:0000255 108..122 6/15 (40%)
Hydrophobic repeat HR-A/B 119..192 29/74 (39%)
Nuclear localization signal. /evidence=ECO:0000255 195..210 9/100 (9%)
Vert_HS_TF 230..512 CDD:368967 67/363 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..337 10/68 (15%)
Hydrophobic repeat HR-C 360..385 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..438 4/30 (13%)
HsfNP_001036555.1 HSF 45..148 CDD:214654 56/103 (54%)
Vert_HS_TF <607..711 CDD:284062 25/111 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155310
Domainoid 1 1.000 126 1.000 Domainoid score I5413
eggNOG 1 0.900 - - E1_COG5169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1154048at2759
OrthoFinder 1 1.000 - - FOG0000255
OrthoInspector 1 1.000 - - otm41758
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10015
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2153
SonicParanoid 1 1.000 - - X160
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.840

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