DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mer and CCDC120

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001156793.2	Gene:	CCDC120 / 90060	HGNCID:	28910	Length:	696	Species:	Homo sapiens

Alignment Length:	319	Identity:	62/319 - (19%)
Similarity:	111/319 - (34%)	Gaps:	105/319 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 QAKEEKQRRQIERKKFIREK---KLRE-------KAE-------------HERYELEK-----SM 354
            |.|.|:.|..::|::.::|.   ||:|       :||             .||.:|.:     :.
Human    61 QVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTAR 125

  Fly   355 EHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECK---ANHFKTEMDRLRERQMKIE-- 414
            .:.......|:.:|..:||......|:....::|:.....:   |....|| .|.|.||::.:
Human   126 AYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTE-QRRRRRQVQADAL 189

  Fly   415 REKHDLEKKIRDA------------------------------DFYVHQLTVENDKREAETEKLR 449
            |..|:||:::||.                              ...:.||:.|:....:|:..|.
Human   190 RRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLS 254

  Fly   450 KELI---------CAKMAEREATARLLEFLN--SG-------------------RKSSTDSLLTA 484
            :...         |..:|||.:..:..:.|.  ||                   .||..:|:.:.
Human   255 ESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASP 319

  Fly   485 SSVSHA-ANTASSMAAISTPSLITSSSTNDLETAGGAELT----THSSHYLVQGDNSSG 538
            :|.:.: ..:|||....|.|      :|..|....|.:|.    .||..:....|:..|
Human   320 TSPTRSLPRSASSFEGRSVP------ATPVLTRGAGPQLCKPEGLHSRQWSGSQDSQMG 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604
		FERM_C_ERM	210..306	CDD:270015
		ERM	341..635	CDD:395622	54/293 (18%)
CCDC120	NP_001156793.2	DUF3338	43..176	CDD:288652	21/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900