DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mer and ccdc120b

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001070919.2	Gene:	ccdc120b / 768286	ZFINID:	ZDB-GENE-061027-93	Length:	615	Species:	Danio rerio

Alignment Length:	284	Identity:	59/284 - (20%)
Similarity:	94/284 - (33%)	Gaps:	92/284 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 KGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIREKKLREKAEHERYELEKSMEHLQN 359
            ||.....|....||....|..|.||         ||...::|:|             :|::.|.|
Zfish     4 KGRVITAMGLGSPDVQGCQDSKLQA---------ERVSELQERK-------------QSLQSLLN 46

  Fly   360 ----EMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF-------------KTEMDRLR 407
                |:|..  .|..:|.|.:|        .....|.|.:...|             |.:.|..:
Zfish    47 SRLGELRQV--CLLEAELTGKL--------PRDFPLEEGERPPFVQRRSGLPPYVTSKGDDDAGQ 101

  Fly   408 ERQMK----------IEREKHDLEKKIRDADFYVH-QLTV-------------ENDKREAETEKL 448
            .||||          |:.:|:.|..| |......| :.||             :|:.........
Zfish   102 RRQMKALFSGALRRSIDSDKNALHSK-RTVHRGCHTEETVKSESSSMSDSTSHDNEDSSPSVAPE 165

  Fly   449 RKELICAKMAEREATARLLEFLN---------SGRKSSTDSLLTASSVSHAANTASSMAAISTPS 504
            .:.|...::|.....:||...|:         :.|.|::.|:..:.|:..:|:.....:..:||.
Zfish   166 HRSLSHPRLAPSSPDSRLCRKLSPVEIYYEMRTRRNSASSSVSPSHSLPRSASNVEGRSVPATPL 230

  Fly   505 LITSSSTNDL------ETAGGAEL 522
            |   |.|..:      |.:||..|
Zfish   231 L---SRTAPISVHVRPEVSGGIAL 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604
		FERM_C_ERM	210..306	CDD:270015	3/10 (30%)
		ERM	341..635	CDD:395622	46/238 (19%)
ccdc120b	NP_001070919.2	DUF3338	12..>86	CDD:288652	22/105 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900