DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and EZR

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001104547.1	Gene:	EZR / 7430	HGNCID:	12691	Length:	586	Species:	Homo sapiens

Alignment Length:	640	Identity:	268/640 - (41%)
Similarity:	381/640 - (59%)	Gaps:	70/640 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:||||||.|||||.|||.:...:|||::|:|..
Human     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSA 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|.   ..|...|.|.|||:||:|:|||||:|||.|||||||:.|||.:|||.||.:|||.|||
Human    68 QEVR---KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..::|.|:.|.:|.|.|:...|:|:.|.||:::|.:.||:||:.|:.:|..|.:|...:|||||
Human   130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||:|||.|.||..|.|||||.::|||||::.||||||..|.|:|||::||:||||.|:.
Human   195 AQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||::..
Human   260 IDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||..|.|:.::.:..|.|.  :|:.:    ..|:||:...|.|...:..:||.| :....
Human   325 TEKKRRETVEREKEQMMREKEELM--LRLQD----YEEKTKKAERELSEQIQRALQLEE-ERKRA 382

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            :.|.:||...:|...|.|.:||                   |:|..:...:|.:.|::||..|..
Human   383 QEEAERLEADRMAALRAKEELE-------------------RQAVDQIKSQEQLAAELAEYTAKI 428

  Fly   465 RLLEFLNSGR-----------KSSTDSLLTASSVSHAANTA--SSMAAISTP-SLITSSSTNDLE 515
            .|||.....:           |.:.|.|:......|...||  .....:..| |.....|..|
Human   429 ALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQD-- 491

  Fly   516 TAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQL 580
              .|||.|.:|:..     :|.||.||         .||.::|| |.|:|        ::||.||
Human   492 --EGAEPTGYSAEL-----SSEGIRDD---------RNEEKRIT-EAEKN--------ERVQRQL 531

  Fly   581 QTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            .||.||::..:.|..:::.||:....::.|.:||.||::::.|:||.|:..||.|
Human   532 LTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	108/201 (54%)
		FERM_C_ERM	210..306	CDD:270015	59/95 (62%)
		ERM	341..635	CDD:395622	81/307 (26%)
EZR	NP_001104547.1	B41	7..206	CDD:214604	108/201 (54%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305\|PubMed:25417112	115..120		3/4 (75%)
		FERM_C_ERM	200..296	CDD:270015	59/95 (62%)
		Interaction with SCYL3. /evidence=ECO:0000269\|PubMed:12651155	244..586		135/394 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..341		17/34 (50%)
		ERM	338..586	CDD:395622	78/300 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..564		31/105 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12147
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820