DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mer and RDX

DIOPT Version :9

Sequence 1:NP_001285458.1 Gene:Mer / 32979 FlyBaseID:FBgn0086384 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_001247421.1 Gene:RDX / 5962 HGNCID:9944 Length:604 Species:Homo sapiens


Alignment Length:640 Identity:265/640 - (41%)
Similarity:380/640 - (59%) Gaps:73/640 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:|:||||.|:|||||||::...:|||:.|:|..
Human     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|:   ..|...|.|.||||||:|||||||||||.|||||||::||:.:|||.||.:|||||||
Human    68 QDVK---KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..:||.|:.|.:|.|.||...|||:.|.:|:::|.|.|||||:.|:.:|..|.|::..||||||
Human   130 VQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..|:|||||.::|||||:..||||||..|.|:|||::||:||||.|:.
Human   195 AQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||.:..
Human   260 IDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||.||.|:..:|:..|.|...::...:...:::  |||        |||.:    ||...
Human   325 NEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQ--KEL--------EEQTR----KALEL 375

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            ..|..|.:|...::|:|:...|    :|...:        .::|..:...:|.:.|::||..|..
Human   376 DQERKRAKEEAERLEKERRAAE----EAKSAI--------AKQAADQMKNQEQLAAELAEFTAKI 428

  Fly   465 RLLEFLNSGRKSSTDSLLTASSVSHAA--------------NTASSMAAISTPSLITSSSTNDLE 515
            .|||   ..:|...:.   |:...|.|              .|..|......|..:...:.|:  
Human   429 ALLE---EAKKKKEEE---ATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENE-- 485

  Fly   516 TAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQL 580
                     |..|.....:.|:.:|:     |.::.....|:...|.::|        ::|:.||
Human   486 ---------HDEHDENNAEASAELSN-----EGVMNHRSEEERVTETQKN--------ERVKKQL 528

  Fly   581 QTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            |.|.||:|..:.|..::..|:|....:|||.:||.||::::.|:||.|:..||.:
Human   529 QALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MerNP_001285458.1 B41 14..216 CDD:214604 116/201 (58%)
FERM_C_ERM 210..306 CDD:270015 60/95 (63%)
ERM 341..635 CDD:395622 71/307 (23%)
RDXNP_001247421.1 B41 7..206 CDD:214604 116/201 (58%)
Phosphatidylinositol binding. /evidence=ECO:0000250 60..63 1/2 (50%)
FERM_C_ERM 200..296 CDD:270015 60/95 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..330 9/19 (47%)
ERM 347..583 CDD:395622 65/291 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 376..407 7/42 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 462..526 13/87 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D281811at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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