Protein Alignment Mer and ezrb

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001025456.1
• Gene: ezrb / 561589
• ZFINID: ZDB-GENE-050803-1
• Length: 583
• Species: Danio rerio
• Alignment Length: 632
• Identity: 265/632 - (41%)
• Similarity: 385/632 - (60%)
• Gaps: 57/632 - (9%)

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:||||||.|||||||:|::..::|||::|:|..
Zfish     3 KPVNVRVTTMDAELEFAVQPSTTGKQLFDQVVKTIGLREIWYFGLQYMDSKGYLTWLKLDKKVSS 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|:   ..|...|.|.||||||:|::||||:|||.|||:|||..|||.:|||.||.:||||||:
Zfish    68 QDVK---KENPLQFKFRAKFFPEDVADELIQDITQKLFFMQVKDGILSDEIYCPPETAVLLASYS 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..::|.:..|.::.|.|....|||:.|.||::::.|.|||||:.|:.:|..|.|::..:|||||
Zfish   130 VQAKFGDFSKELHRPGYLTSERLLPQRVLDQHKLSREQWEERIQVWHEEHRGMLREDAMLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..|:|||||.::|||||::.||||||..|.|:|||::||:||||.|:.
Zfish   195 AQDLEMYGVNYFDIKNKKGTELWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:||||::|:||.:..
Zfish   260 IDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKQQKQMERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||..|.|:.::|:..:.|..::      .:..|.||::..|.    :||||
Zfish   325 NEKKRREAIEREKEQMEREKKELMMQL------YQFEERTKKVENEL----QEQMQ--------- 370

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
                   |..|::.||...|.|....:|:.....|..|...|:|:.:...:|.:.|::||..|..
Zfish   371 -------RAMQLQHERRLADEEAARLEAERQAALLAKEELARQAQDQLKSQEQLAAELAEYTAKI 428

  Fly   465 RLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLI-TSSSTNDLETA----GGAELTT 524
            .|||   ..:|...:.          |.|..:.|.::...|| |....:::.||    .......
Zfish   429 SLLE---EAKKRKEEE----------AQTWQNKAQLAQDDLIKTRQELHNVMTAPPLPPPPPAYD 480

  Fly   525 HSSHYLVQGDNSSG-ISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIA 588
            |..:.|..|:.|:| .:.|.:...|.....|.|:|| |.|:|        ::||.||..|.||:|
Zfish   481 HDENDLDDGEESNGSYTADLQTGGFNDHRLEEERIT-EAEKN--------ERVQKQLLALTSELA 536

  Fly   589 PHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ..:.:..::..|:|....::||.:||.||::::.|:||.|:..||.|
Zfish   537 QARDDTKKTQNDLLHTENVRAGRDKYKTLRQIRQGNTKQRIDEFEAL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	108/201 (54%)
		FERM_C_ERM	210..306	CDD:270015	60/95 (63%)
		ERM_helical	340..459	CDD:466641	27/118 (23%)
		ERM_C	559..635	CDD:459932	26/75 (35%)
ezrb	NP_001025456.1	B41	7..206	CDD:214604	108/201 (54%)
		FERM_C_ERM	200..296	CDD:270015	60/95 (63%)
		ERM_helical	337..456	CDD:466641	33/157 (21%)
		ERM_C	507..583	CDD:459932	29/84 (35%)