DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and ezrb

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001025456.1	Gene:	ezrb / 561589	ZFINID:	ZDB-GENE-050803-1	Length:	583	Species:	Danio rerio

Alignment Length:	632	Identity:	265/632 - (41%)
Similarity:	385/632 - (60%)	Gaps:	57/632 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:||||||.|||||||:|::..::|||::|:|..
Zfish     3 KPVNVRVTTMDAELEFAVQPSTTGKQLFDQVVKTIGLREIWYFGLQYMDSKGYLTWLKLDKKVSS 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|:   ..|...|.|.||||||:|::||||:|||.|||:|||..|||.:|||.||.:||||||:
Zfish    68 QDVK---KENPLQFKFRAKFFPEDVADELIQDITQKLFFMQVKDGILSDEIYCPPETAVLLASYS 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..::|.:..|.::.|.|....|||:.|.||::::.|.|||||:.|:.:|..|.|::..:|||||
Zfish   130 VQAKFGDFSKELHRPGYLTSERLLPQRVLDQHKLSREQWEERIQVWHEEHRGMLREDAMLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..|:|||||.::|||||::.||||||..|.|:|||::||:||||.|:.
Zfish   195 AQDLEMYGVNYFDIKNKKGTELWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:||||::|:||.:..
Zfish   260 IDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKQQKQMERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||..|.|:.::|:..:.|..::      .:..|.||::..|.    :||||
Zfish   325 NEKKRREAIEREKEQMEREKKELMMQL------YQFEERTKKVENEL----QEQMQ--------- 370

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
                   |..|::.||...|.|....:|:.....|..|...|:|:.:...:|.:.|::||..|..
Zfish   371 -------RAMQLQHERRLADEEAARLEAERQAALLAKEELARQAQDQLKSQEQLAAELAEYTAKI 428

  Fly   465 RLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLI-TSSSTNDLETA----GGAELTT 524
            .|||   ..:|...:.          |.|..:.|.::...|| |....:::.||    .......
Zfish   429 SLLE---EAKKRKEEE----------AQTWQNKAQLAQDDLIKTRQELHNVMTAPPLPPPPPAYD 480

  Fly   525 HSSHYLVQGDNSSG-ISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIA 588
            |..:.|..|:.|:| .:.|.:...|.....|.|:|| |.|:|        ::||.||..|.||:|
Zfish   481 HDENDLDDGEESNGSYTADLQTGGFNDHRLEEERIT-EAEKN--------ERVQKQLLALTSELA 536

  Fly   589 PHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ..:.:..::..|:|....::||.:||.||::::.|:||.|:..||.|
Zfish   537 QARDDTKKTQNDLLHTENVRAGRDKYKTLRQIRQGNTKQRIDEFEAL 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	108/201 (54%)
		FERM_C_ERM	210..306	CDD:270015	60/95 (63%)
		ERM	341..635	CDD:395622	77/299 (26%)
ezrb	NP_001025456.1	B41	7..206	CDD:214604	108/201 (54%)
		FERM_N	9..71	CDD:286467	33/61 (54%)
		FERM_M	92..206	CDD:278785	62/113 (55%)
		FERM_C_ERM	200..296	CDD:270015	60/95 (63%)
		GBP_C	<305..417	CDD:303769	41/137 (30%)
		DUF106	<306..>350	CDD:303007	20/43 (47%)
		ERM	338..583	CDD:279153	74/292 (25%)
		coiled coil	387..398	CDD:293879	1/10 (10%)
		coiled coil	407..417	CDD:293879	2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820