DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and nf2a

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001122179.1	Gene:	nf2a / 561184	ZFINID:	ZDB-GENE-080722-7	Length:	593	Species:	Danio rerio

Alignment Length:	629	Identity:	289/629 - (45%)
Similarity:	403/629 - (64%)	Gaps:	51/629 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKR 71
            |:.:..:|.|.|.|::|||..|.:..|:|||:|||||:||||:|:|||:| |.:..|:||||:|:
Zfish    16 KQAKIFNVTVVTMDADLEFSCELKWRGKDLFELVCRTLGLRETWFFGLRY-DVKDTVAWLKMDKK 79

  Fly    72 VRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLA 136
            |.|..|   ......||.|.|||:||||.|||:|:|||||||||||:|||..:|||.||||||||
Zfish    80 VLDHDV---PKEEPIVFYFLAKFYPENVEEELVQDITQHLFFLQVKKSILEEEIYCPPEASVLLA 141

  Fly   137 SYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEY 201
            |||||.:||.|:...:|.|.|:..|||||.|.:.||||.|||||||...|.:|...||||.||||
Zfish   142 SYAVHAKYGDYNPNVHKPGFLSQDELLPKRVINLYQMTAEMWEERITVCYAEHRGRTRDEAEMEY 206

  Fly   202 LKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFT 266
            |||||||:|||||||.|.||..|.|.|||.::||:|||..::||||.:|.|||||::|:.||:|.
Zfish   207 LKIAQDLEMYGVNYFSIRNKKGTSLLLGVDALGLHIYDLDNRLTPKISFPWNEIRNISYSDKEFA 271

  Fly   267 IRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERK 331
            |:.||.:...|.|.|..|.:||:||.||.|||||:||||:.|::|:||||.||:|||.|:|:||:
Zfish   272 IKPVDKRADVFKFNSSKLRVNKLILQLCIGNHDLFMRRRRVDSLEVQQMKTQAREEKARKQMERQ 336

  Fly   332 KFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKA 396
            :..|||:|||.||..|.||::.:..||:|..:||:||.|||||.:|..||:::.||:.:|...||
Zfish   337 RLEREKQLREDAERARDELQRRLIQLQDEAHLANEALLRSEETADLLAEKAQIAEEEAKLLAQKA 401

  Fly   397 NHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAERE 461
            ...:.||.|::...::.|.||..:|:|:.:|:....::..|:::|..|.::|:::|..|:.:||.
Zfish   402 AEAEQEMQRIKVTAIRSEEEKRLMEQKMLEAEMIALKMAEESERRAKEADQLKQDLQEARESERR 466

  Fly   462 ATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHS 526
            |..:|||.                    .:.|..|...:|..||          .|.|.....
Zfish   467 AKNKLLEI--------------------TSKTEYSPVPLSANSL----------PADGPNFNF-- 499

  Fly   527 SHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHK 591
                    :...:|.||:       |.:|::::.|:|:..::|:..||.:|.||..|::||...|
Zfish   500 --------SMENLSFDFK-------DTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIESLK 549

  Fly   592 IEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ::|.::.||||.....:.|.:|.|..|||...|||:|||||:||
Zfish   550 LKERETPLDILHNENTEKGTSKQSNFKKLTLQSTKSRVAFFQEL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	125/201 (62%)
		FERM_C_ERM	210..306	CDD:270015	55/95 (58%)
		ERM	341..635	CDD:395622	90/293 (31%)
nf2a	NP_001122179.1	B41	23..221	CDD:214604	125/201 (62%)
		FERM_N	25..85	CDD:286467	34/60 (57%)
		FERM_M	106..221	CDD:278785	79/114 (69%)
		FERM_C_ERM	215..311	CDD:270015	55/95 (58%)
		SKIP_SNW	<323..354	CDD:280827	18/30 (60%)
		GBP_C	<334..462	CDD:303769	48/127 (38%)
		ERM	346..593	CDD:279153	90/293 (31%)
		coiled coil	453..462	CDD:293879	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594828
Domainoid	1	1.000	168	1.000	Domainoid score	I3791
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2180
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1197
OMA	1	1.010	-	-		QHG50050
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	1	1.000	-	-		FOG0006349
OrthoInspector	1	1.000	-	-		otm26489
orthoMCL	1	0.900	-	-		OOG6_105659
Panther	1	1.100	-	-	O	PTHR23281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4654
SonicParanoid	1	1.000	-	-		X4049
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800