Protein Alignment Mer and INAVA

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_060735.4
• Gene: INAVA / 55765
• HGNCID: 25599
• Length: 663
• Species: Homo sapiens
• Alignment Length: 143
• Identity: 33/143 - (23%)
• Similarity: 56/143 - (39%)
• Gaps: 37/143 - (25%)

  Fly   323 KQRRQIE----------RKKFIREKKLREKAEHERYELE------KSMEHLQNEMRMANDALRRS 371
            ||:|.:|          |:..:||.:|......| |.|:      |....:....::.:.||.|.
Human   121 KQQRALEARLEACLEELRRLCLREAELTGTLPAE-YPLKPGEKAPKVRRRIGAAYKLDDWALHRE 184

  Fly   372 EETKELYFEKSRVNEEQMQLTE-----CKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYV 431
            :....|    .|....|:|:||     |...:...:..|.|:..|..|      |||:::    :
Human   185 DPLSSL----ERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQE------EKKLQE----L 235

  Fly   432 HQLTVENDKREAE 444
            .:..||. :|.:|
Human   236 QRCLVER-RRNSE 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604
		FERM_C_ERM	210..306	CDD:270015
		ERM_helical	340..459	CDD:466641	25/116 (22%)
		ERM_C	559..635	CDD:459932
INAVA	NP_060735.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		CUPID	87..216	CDD:463360	22/99 (22%)
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000269|PubMed:28436939	164..170		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..362		2/7 (29%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000269|PubMed:28436939	332..338
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..425
		Nuclear localization signal (NLS) 3. /evidence=ECO:0000269|PubMed:28436939	422..428
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..493