Protein Alignment Mer and msnb

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001243180.1
• Gene: msnb / 553434
• ZFINID: ZDB-GENE-030717-7
• Length: 577
• Species: Danio rerio
• Alignment Length: 639
• Identity: 255/639 - (39%)
• Similarity: 371/639 - (58%)
• Gaps: 77/639 - (12%)

  Fly    11 SLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQ 75
            |::|||:|.|:||||.::...:|:.|||.|.:||||||.|||||||.|::...:|||:.|||..|
Zfish     2 SINVRVTTMDAELEFAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYQDSKGFSTWLKLNKRVTAQ 66

  Fly    76 RVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAV 140
            .|.   ..|..:..|.|||:||:|:||||||.||.|||||||::||:.||||.||.:||||||||
Zfish    67 DVR---KENPLLIKFRAKFYPEDVAEELIQEATQRLFFLQVKEAILNDDIYCPPETAVLLASYAV 128

  Fly   141 HVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKIA 205
            .:::..|:.|.:..|.|...:|||:.|.:|:::|.|.||:||:.|:..|:.|:|::..:|||||:
Zfish   129 QMKHSDYNSEHHIPGYLCRDKLLPQRVLEQHKLTKEQWEQRIQVWHEQHKSMSREDAMIEYLKIS 193

  Fly   206 QDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLV 270
            |||:|||||||.|.||..::|||||.::|||||:..||||||..|.|:|||::||:||||.|:.:
Zfish   194 QDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYERSDKLTPKIGFPWSEIRNISFNDKKFVIKPI 258

  Fly   271 DAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIR 335
            |.|..:|:||:..|.|||.||.||.||||||||||||||:|:|||||||:|||.:||.||.....
Zfish   259 DKKSPDFVFYAPRLRINKRILALCMGNHDLYMRRRKPDTIEVQQMKAQAREEKNKRQQERALLEN 323

  Fly   336 EKKLREKAEHERYELEKSMEHLQNEMRMANDALRRS-----EETK---ELYFEKSRVNEEQMQLT 392
            |||.||.||.|..::.:....|...:|...:..:::     |:||   ||..|:....||..:|.
Zfish   324 EKKRRENAEKETEKIARETMELMERLRQIEEQTKKAQEELEEQTKRALELERERKFAQEEAEKLE 388

  Fly   393 ECK--ANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICA 455
            :.:  |...||.:.:..|.|.|   .|.:|..::.:....::.|.....|:|.|..|.::..|..
Zfish   389 KDRRIAEDVKTALLQQSENQTK---NKDNLATELAELTSKINLLEDAKKKKEDEARKWQRRAIMV 450

  Fly   456 KM----AEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLET 516
            ::    .:.|..::|:. ::....|.|::       .|..|..||..|
Zfish   451 EVDLEKTKEELKSKLIG-VHIQATSQTEN-------DHDENDESSAEA----------------- 490

  Fly   517 AGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQ 581
              .||||:..|                      ..|...||...|.|:|        :.:|.:||
Zfish   491 --SAELTSTGS----------------------FRDRSEEQRITETEKN--------EPLQKRLQ 523

  Fly   582 TLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            .|.||:|..:.:..::..|::....::.|.:||.||::::.|:||.|:..||.:
Zfish   524 ALSSELADARDDSKKTANDLIHAENVRLGRDKYKTLRQIRQGNTKQRIDEFESM 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	107/201 (53%)
		FERM_C_ERM	210..306	CDD:270015	60/95 (63%)
		ERM_helical	340..459	CDD:466641	30/132 (23%)
		ERM_C	559..635	CDD:459932	22/75 (29%)
msnb	NP_001243180.1	B41	5..204	CDD:214604	107/201 (53%)
		FERM_C_ERM	198..294	CDD:270015	60/95 (63%)
		ERM_helical	336..454	CDD:466641	25/120 (21%)
		ERM_C	502..577	CDD:459932	25/82 (30%)