DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and Ezr

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_062230.1	Gene:	Ezr / 54319	RGDID:	621161	Length:	586	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	262/637 - (41%)
Similarity:	380/637 - (59%)	Gaps:	64/637 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:||||||.|||||||||.:...:|||::|:|..
  Rat     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSA 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|.   ..|...|.|.|||:||:|::||||:|||.|||||||:.|||.:|||.||.:|||.|||
  Rat    68 QEVR---KENPVQFKFRAKFYPEDVADELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..::|.|:.|.:|.|.|:...|:|:.|.||::::.:.||:||:.|:.:|..|.:|...:|||||
  Rat   130 VQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||:|||.|.||..|.|||||.::|||||::.||||||..|.|:|||::||:||||.|:.
  Rat   195 AQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||::..
  Rat   260 IDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||..|.|:.::.:..|.|...::......:|:|  |||    |...|:.:||.| :....
  Rat   325 TEKKRRETVEREKEQMLREKEELMLRLQDFEQKTKRAE--KEL----SEQIEKALQLEE-ERRRA 382

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            :.|.:||...:|...|.|.:||                   |:|:.:...:|.:.|::||..|..
  Rat   383 QEEAERLEADRMAALRAKEELE-------------------RQAQDQIKSQEQLAAELAEYTAKI 428

  Fly   465 RLLEFLNSGR-----------KSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAG 518
            .|||.....:           |.:.|.|:......|...||...........:.......|:..
  Rat   429 ALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDE- 492

  Fly   519 GAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTL 583
            |||...:|:..     :|.||.||         .||.::|| |.|:|        ::||.||.||
  Rat   493 GAEPMGYSAEL-----SSEGILDD---------RNEEKRIT-EAEKN--------ERVQRQLLTL 534

  Fly   584 RSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            .:|::..:.|..:::.||:....::.|.:||.||::::.|:||.|:..||.:
  Rat   535 SNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	107/201 (53%)
		FERM_C_ERM	210..306	CDD:270015	59/95 (62%)
		ERM	341..635	CDD:395622	77/304 (25%)
Ezr	NP_062230.1	B41	7..206	CDD:214604	107/201 (53%)
		FERM_N	9..71	CDD:286467	34/61 (56%)
		FERM_M	92..206	CDD:278785	61/113 (54%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000250\|UniProtKB:P15311	115..120		3/4 (75%)
		FERM_C_ERM	200..296	CDD:270015	59/95 (62%)
		Interaction with SCYL3. /evidence=ECO:0000250	244..586		131/391 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..338		17/31 (55%)
		ERM	338..586	CDD:279153	74/297 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11798
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820