DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mer and NF2

DIOPT Version :9

Sequence 1:NP_001285458.1 Gene:Mer / 32979 FlyBaseID:FBgn0086384 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_000259.1 Gene:NF2 / 4771 HGNCID:7773 Length:595 Species:Homo sapiens


Alignment Length:630 Identity:294/630 - (46%)
Similarity:409/630 - (64%) Gaps:52/630 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 KKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKR 71
            |:.::.:||:.|.|:|:||..|.:..|:|||||||||:||||:|:|||||. .:..|:||||:|:
Human    17 KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKK 80

  Fly    72 VRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLA 136
            |.|..|   :......|.|.|||:|||..|||:|||||||||||||:.||...|||.||||||||
Human    81 VLDHDV---SKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLA 142

  Fly   137 SYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEY 201
            ||||..:||.||...:|.|.||..|||||.|.:.||||||||||||..||.:|....|||.||||
Human   143 SYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207

  Fly   202 LKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFT 266
            |||||||:|||||||.|.||..|:|.|||.::||:|||..::||||.:|.|||||::|:.||:||
Human   208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFT 272

  Fly   267 IRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERK 331
            |:.:|.|:..|.|.|..|.:||:||.||.|||||:|||||.|::|:|||||||:|||.|:|:||:
Human   273 IKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQ 337

  Fly   332 KFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKA 396
            :..|||::||:||..|.|||:.:..::.|..|||:||.|||||.:|..||:::.||:.:|...||
Human   338 RLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 402

  Fly   397 NHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAERE 461
            ...:.||.|::...::.|.||..:|:|:.:|:....::..|:::|..|.::|:::|..|:.|||.
Human   403 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERR 467

  Fly   462 ATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHS 526
            |..:|||....                   .|...|..|..|                  |....
Human   468 AKQKLLEIATK-------------------PTYPPMNPIPAP------------------LPPDI 495

  Fly   527 SHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHK 591
            ..:.:.||:   :|.||:       |.:|::::.|:|:..::|:..||.:|.||..|::||...|
Human   496 PSFNLIGDS---LSFDFK-------DTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550

  Fly   592 IEENQSNLDIL-SEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ::|.::.|||| :|...:.|.:|::|:|||...|.|:||||||||
Human   551 LKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MerNP_001285458.1 B41 14..216 CDD:214604 126/201 (63%)
FERM_C_ERM 210..306 CDD:270015 56/95 (59%)
ERM 341..635 CDD:395622 92/294 (31%)
NF2NP_000259.1 B41 23..222 CDD:214604 126/202 (62%)
FERM_C_ERM 216..312 CDD:270015 56/95 (59%)
PLN03086 307..>367 CDD:178635 32/59 (54%)
ERM 347..595 CDD:366293 92/294 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158869
Domainoid 1 1.000 166 1.000 Domainoid score I3909
eggNOG 1 0.900 - - E1_KOG3529
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2180
Inparanoid 1 1.050 545 1.000 Inparanoid score I1169
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50050
OrthoDB 1 1.010 - - D281811at33208
OrthoFinder 1 1.000 - - FOG0006349
OrthoInspector 1 1.000 - - oto88360
orthoMCL 1 0.900 - - OOG6_105659
Panther 1 1.100 - - O PTHR23281
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4654
SonicParanoid 1 1.000 - - X4049
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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