Protein Alignment Mer and rdx

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_002938008.3
• Gene: rdx / 447978
• XenbaseID: XB-GENE-990892
• Length: 590
• Species: Xenopus tropicalis
• Alignment Length: 642
• Identity: 272/642 - (42%)
• Similarity: 386/642 - (60%)
• Gaps: 70/642 - (10%)

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:|:||||.|:|||||||::...:|||:.|:|..
 Frog     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|.   ..|...|.|.||||||:|||||||||||.|||||||::||:.:|||.||.:|||||||
 Frog    68 QDVR---KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..:||.|..|.:|.|.||...|||:.|.:|:::|.|.|||||:||:.:|..|.|::..||||||
 Frog   130 VQAKYGDYSKEAHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQTWHEEHRSMLREDSMMEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..|:|||||.::|||||:..||||||..|.|:|||::||:||||.|:.
 Frog   195 AQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||.:..
 Frog   260 IDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||.||.|:..:|:..:.|...:|...:...:::  |||        |||.:    ||...
 Frog   325 NEKKKREIAEKEKERIEREKDELIERLRQIEEQTLKAQ--KEL--------EEQTR----KALEL 375

  Fly   400 KTEMDRLRERQMKIEREKHDLEK-KIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREAT 463
            ..|..|.:|...::|:|:...|: |...|             ::|..:...:|.:.|::||..|.
 Frog   376 DQERKRAKEEAERLEKERQAAEEAKSALA-------------KQAADQMKNQEQLAAELAEFTAK 427

  Fly   464 ARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAE------- 521
            ..|||   ..:|...:.   ||...|.|.||..         ....:..:|:|...|.
 Frog   428 IALLE---EAKKKKEEE---ASEWQHKAYTAQE---------DLEKTKEELKTVMSAPPPPPPPQ 477

  Fly   522 -------LTTHSSH-YLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQS 578
                   ..|.:.| :..|.:||:..|.:...:..:...:|.|::| |.::|        ::|:.
 Frog   478 LLPPPPVAPTENEHDHDEQDENSAEASAELSSEGVMNHRSEEERLT-ETQKN--------ERVKK 533

  Fly   579 QLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            |||.|.||:|..:.|..::..|:|....:|||.:||.||::::.|:||.|:..||.:
 Frog   534 QLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	117/201 (58%)
		FERM_C_ERM	210..306	CDD:270015	60/95 (63%)
		ERM_helical	340..459	CDD:466641	27/119 (23%)
		ERM_C	559..635	CDD:459932	27/75 (36%)
rdx	XP_002938008.3	B41	7..206	CDD:214604	117/201 (58%)
		FERM_C_ERM	200..296	CDD:270015	60/95 (63%)
		ERM_helical	345..456	CDD:466641	34/152 (22%)
		ERM_C	514..590	CDD:459932	29/84 (35%)