DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and nf2b

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_998116.1	Gene:	nf2b / 405887	ZFINID:	ZDB-GENE-040622-3	Length:	586	Species:	Danio rerio

Alignment Length:	642	Identity:	295/642 - (45%)
Similarity:	404/642 - (62%)	Gaps:	63/642 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSPFGSKKN--RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNV 63
            ||..|.||.  ::..|:|||.|:|:||..|.:..|:||||||||||||||:|:|||:|. .:...
Zfish     1 MSILGLKKKQPKTFKVKVSTMDAEMEFSCEVKWKGKDLFDLVCRTIGLRETWFFGLRYT-VKDTY 64

  Fly    64 SWLKMEKRVRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCR 128
            :|||.:|||.||.|   ..::...|.|.||||||.|.:||:|||||||||||||:.||..:|:|.
Zfish    65 AWLKPDKRVLDQEV---PKDSPITFHFLAKFFPEKVEDELVQEITQHLFFLQVKKQILDEEIFCS 126

  Fly   129 PEASVLLASYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMT 193
            ||||||||||||..:||.||...:|.|.||..|||||.|..||||||:||||:|..||.:|..:|
Zfish   127 PEASVLLASYAVQAKYGDYDPNFHKPGFLAQDELLPKRVLMQYQMTPDMWEEKITAWYAEHRNIT 191

  Fly   194 RDEVEMEYLKIAQDLDMYGVNYFPIT-NKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRH 257
            |||.||||||||||||||||:||.|| ||..|:|.|||.:.||:||:..:||:|..:|.|:.||:
Zfish   192 RDEAEMEYLKIAQDLDMYGVSYFSITQNKRDTELLLGVDAQGLHIYNPNNKLSPNKSFPWSGIRN 256

  Fly   258 VSFDDKKFTIRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEE 322
            :|:.:|:|||:.:|.|...|.|||..|.:||:||.||.|||||:|||||.|::|:||||||||||
Zfish   257 ISYSEKEFTIKPLDKKKEVFKFYSSQLRVNKLILQLCIGNHDLFMRRRKVDSIEVQQMKAQAKEE 321

  Fly   323 KQRRQIERKKFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEE 387
            |.|:::||:...|||::||:||..:.|:|:.|..||:|.||||:||.|||||.:|..||:::.||
Zfish   322 KARKKVERQILAREKQMREEAERAKEEMERRMFQLQDEARMANEALLRSEETADLLAEKAQIAEE 386

  Fly   388 QMQLTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKEL 452
            :.:|...||...:.|..||....:|.:.||..:|:|:|:|:....:|..::::|..|.:.|:::|
Zfish   387 EAKLLAHKAAEAEQERQRLEVTALKTKEEKRLMEQKMREAEQLAVKLVEQSERRLKEADHLKQDL 451

  Fly   453 ICAKMAEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETA 517
            ..||.|||.|..:|||...:                    |...:||.|.|           ...
Zfish   452 NEAKDAERRAKQKLLEITKT--------------------TYPLIAAYSNP-----------PPP 485

  Fly   518 GGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQT 582
            .|.|    |....::..|.  |..||:       |::|::::.|:||..|:|:..||.:|.||:.
Zfish   486 AGPE----SPEMAIEMGNP--IQMDFK-------DSDMKRLSMEIERERLEYMEKSKHLQDQLKE 537

  Fly   583 LRSEIAPHKIEENQS----NLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            |:|||...|:||.|.    ||...:|.......|:.|        :..|::||:||:
Zfish   538 LKSEIESLKLEEQQQAGVYNLRSYAEPPFIPPSNRNS--------AYMAQMAFYEEV 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	126/201 (63%)
		FERM_C_ERM	210..306	CDD:270015	52/96 (54%)
		ERM	341..635	CDD:395622	93/297 (31%)
nf2b	NP_998116.1	B41	15..214	CDD:214604	126/202 (62%)
		FERM_N	18..76	CDD:286467	34/58 (59%)
		FERM_M	100..214	CDD:278785	79/113 (70%)
		FERM_C_ERM	208..305	CDD:270015	52/96 (54%)
		ERM	346..551	CDD:279153	80/248 (32%)
		GBP_C	<362..467	CDD:303769	40/104 (38%)
		coiled coil	454..465	CDD:293879	6/10 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594829
Domainoid	1	1.000	168	1.000	Domainoid score	I3791
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1197
OMA	1	1.010	-	-		QHG50050
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	1	1.000	-	-		FOG0006349
OrthoInspector	1	1.000	-	-		otm26489
orthoMCL	1	0.900	-	-		OOG6_105659
Panther	1	1.100	-	-	LDO	PTHR23281
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4049
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870