Protein Alignment Mer and ezra

DIOPT Version :9

• Sequence 1: NP_001285458.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001018326.1
• Gene: ezra / 403009
• ZFINID: ZDB-GENE-050522-18
• Length: 595
• Species: Danio rerio
• Alignment Length: 654
• Identity: 263/654 - (40%)
• Similarity: 381/654 - (58%)
• Gaps: 89/654 - (13%)

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::...:|:.||:.|.:|:||||.||||||:.|.:..::|||::|:|..
Zfish     3 KPINVRVTTMDAELEFAIQSVTTGKQLFEQVVKTVGLREIWYFGLQFTDNKGFLTWLKLDKKVSS 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|:   ..|...|.|.||.:||:|||||||:||:.|||||||:||||.:|||.||.:|||||||
Zfish    68 QEVK---QENPLQFKFRAKHYPEDVSEELIQDITKKLFFLQVKESILSDEIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..::|.:..||:|.|.|:...|||:.|.||::::.|.|||||:.|:.:|..:.:::..:|||||
Zfish   130 VQSKFGDFTPETHKTGYLSSERLLPQRVLDQHKLSKEQWEERIQIWHEEHRGILKEDSMLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            :|||:|||||||.|.||..|.|||||.::|||||::.|:||||..|.|:|||::||:||||.|:.
Zfish   195 SQDLEMYGVNYFDIKNKKGTDLWLGVDALGLNIYEKDDRLTPKIGFPWSEIRNISFNDKKFIIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:|||:||||||:|:|||||||:|||.:||:||.:..
Zfish   260 IDKKAPDFVFYASRLRINKRILQLCMGNHELYMKRRKPDTIEVQQMKAQAREEKHQRQMERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||..|.|:..:||..:.:..::....:..::.|......||::||
Zfish   325 NEKKKREAIEKEKEMVEKEKQEMMMKLYQFEEQTKKVERDLREQFERARV--------------- 374

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
                  |.|.:.|:|.|...||     |:.....:..|...|:||.:...:|.:.|.:||..|..
Zfish   375 ------LEEERRKVEEEAARLE-----AERQAALMAKEELARQAEDQMKTQEQLAADLAEYTAKL 428

  Fly   465 RLL------------EFLNSGRKSSTDSLLT--------ASSVSHAANTASSMAAISTPSLITSS 509
            .||            |:.|..::...|...|        ||.|:.|...||..|.::..:::...
Zfish   429 ALLEEARRIKEEEANEWQNRAKEVQDDLEKTREELHNVMASPVAAAPMAASMAAPMAARAMMEEP 493

  Fly   510 STNDLETAGGAELTTHSSHYLVQGDNSS--------GISDDFEPKEFILTDNEMEQITNEMERNH 566
            ..||           |..|   :.:||:        ||.|.         .||.|:|| |.|:|
Zfish   494 LEND-----------HEDH---EENNSTYSAELPVEGIEDH---------RNEEERIT-EAEKN- 533

  Fly   567 LDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAF 631
                   ::||.||..|.||:|..:....::..|||....::||.:||.||::::.|:||.|:..
Zfish   534 -------ERVQKQLMALSSELAEARDNTKKTQNDILHSENVQAGRDKYKTLRQIRMGNTKQRIDE 591

  Fly   632 FEEL 635
            ||.|
Zfish   592 FEAL 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	105/201 (52%)
		FERM_C_ERM	210..306	CDD:270015	58/95 (61%)
		ERM	341..635	CDD:395622	80/321 (25%)
ezra	NP_001018326.1	B41	7..206	CDD:214604	105/201 (52%)
		FERM_N	9..71	CDD:286467	29/61 (48%)
		FERM_M	91..206	CDD:278785	64/114 (56%)
		FERM_C_ERM	200..296	CDD:270015	58/95 (61%)
		ERM	347..595	CDD:279153	75/305 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820