Protein Alignment Mer and Rdx

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001420682.1
• Gene: Rdx / 315655
• RGDID: 1359472
• Length: 604
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 269/642 - (41%)
• Similarity: 386/642 - (60%)
• Gaps: 77/642 - (11%)

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:|:||||.|:|||||||::...:|||:.|:|..
  Rat     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|:   ..|...|.|.||||||:|||||||||||.|||||||::||:.:|||.||.:|||||||
  Rat    68 QDVK---KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..:||.|:.|.:|.|.||...|||:.|.:|:::|.|.|||||:.|:.:|..|.|::..||||||
  Rat   130 VQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..|:|||||.::|||||:..||||||..|.|:|||::||:||||.|:.
  Rat   195 AQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||.:..
  Rat   260 IDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||.||.|:..:|:..|.|...:|...:...:::  |||        |||.:    ||...
  Rat   325 NEKKKREIAEKEKERIEREKEELMERLRQIEEQTMKAQ--KEL--------EEQTR----KALEL 375

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            :.|..|.:|...:::||:...|    :|...:        .::|..:...:|.:.|::||..|..
  Rat   376 EQERQRAKEEAERLDRERRAAE----EAKSAI--------AKQAADQMKNQEQLAAELAEFTAKI 428

  Fly   465 RLLEFLNSGRKSSTDSLLTASSVSHAANTASS------------MAAISTPS----LITSSSTND 513
            .|||   ..:|...:.   |:...|.|..|..            |.|...|.    :..:.:.:|
  Rat   429 ALLE---EAKKKKEEE---ATEWQHKAFAAQEDLEKTKEELKTVMCAPPPPPPPAVVPPTENEHD 487

  Fly   514 LETAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQS 578
            .:....||.:...|        |.|:::.         .:|.|::| |.::|        ::|:.
  Rat   488 EQDEHSAEASAELS--------SEGVTNH---------RSEEERVT-ETQKN--------ERVKK 526

  Fly   579 QLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            |||.|.||:|..:.|..::..|:|....:|||.:||.||::::.|:||.|:..||.:
  Rat   527 QLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	116/201 (58%)
		FERM_C_ERM	210..306	CDD:270015	60/95 (63%)
		ERM_helical	340..459	CDD:466641	27/118 (23%)
		ERM_C	559..635	CDD:459932	27/75 (36%)
Rdx	NP_001420682.1	B41	7..206	CDD:214604	116/201 (58%)
		FERM_C_ERM	200..296	CDD:270015	60/95 (63%)
		ERM_helical	347..456	CDD:466641	31/140 (22%)
		ERM_C	507..583	CDD:459932	29/93 (31%)