Protein Alignment Mer and Nf2

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_063128952.1
• Gene: Nf2 / 25744
• RGDID: 3169
• Length: 653
• Species: Rattus norvegicus
• Alignment Length: 688
• Identity: 294/688 - (42%)
• Similarity: 409/688 - (59%)
• Gaps: 110/688 - (15%)

  Fly     7 KKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKR 71
            |:.::.:||:.|.|:|:||..|.:..|:|||||||||:||||:|:|||||. .:..|:||||:|:
  Rat    17 KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKK 80

  Fly    72 VRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLA 136
            |.|..|   :......|.|.|||:|||..|||:|||||||||||||:.||...:||.||||||||
  Rat    81 VLDHDV---SKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLA 142

  Fly   137 SYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEY 201
            ||||..:||.||...:|.|.||..|||||.|.:.||||||||||||..||.:|....|||.||||
  Rat   143 SYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207

  Fly   202 LKIAQDLDMYGVNYFPIT----------------------------------------------- 219
            |||||||:|||||||.|.
  Rat   208 LKIAQDLEMYGVNYFTIRHSGGRSRRISVSSNVSLKPAWSTELSSRTTRTTQKKLSKTKTEFLAN 272

  Fly   220 ----------NKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAKV 274
                      ||..|:|.|||.::||:|||..::||||.:|.|||||::|:.||:|||:.:|.|:
  Rat   273 LFYLEEEEKYNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKI 337

  Fly   275 SNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIREKKL 339
            ..|.|.|..|.:||:||.||.|||||:|||||.|::|:|||||||:|||.|:|:||::..|||::
  Rat   338 DVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQM 402

  Fly   340 REKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHFKTEMD 404
            ||:||..|.|||:.:..::.|..|||:||.|||||.:|..||:::.||:.:|...||...:.||.
  Rat   403 REEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQ 467

  Fly   405 RLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATARLLEF 469
            |::...::.|.||..:|:|:.:|:....::..|:::|..|.::|:::|..|:.|||.|..:|||.
  Rat   468 RIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEI 532

  Fly   470 LNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHYLVQGD 534
            ...                   .|...|..|..|                  |......:.:.||
  Rat   533 ATK-------------------PTYPPMNPIPAP------------------LPPDIPSFDIIGD 560

  Fly   535 NSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNL 599
            :   :|.||:       |.:|::::.|:|:..::|:..||.:|.||..|::||...|::|.::.|
  Rat   561 S---LSFDFK-------DTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETAL 615

  Fly   600 DIL-SEAQIKAG-ENKYSTLKKLKSGSTKARVAFFEEL 635
            ||| ||...:.| .:|::|:|||...|.|:||||||||
  Rat   616 DILHSEHSDRGGTSSKHNTIKKLTLQSAKSRVAFFEEL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	125/201 (62%)
		FERM_C_ERM	210..306	CDD:270015	56/152 (37%)
		ERM_helical	340..459	CDD:466641	42/118 (36%)
		ERM_C	559..635	CDD:459932	33/77 (43%)
Nf2	XP_063128952.1	None