DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and mto1

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_588284.1	Gene:	mto1 / 2539467	PomBaseID:	SPCC417.07c	Length:	1115	Species:	Schizosaccharomyces pombe

Alignment Length:	751	Identity:	143/751 - (19%)
Similarity:	268/751 - (35%)	Gaps:	223/751 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSPFGSKKN----------RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQ 55
            ::|...::|          .:||.::|..       |.|.::.:||.|
pombe   191 LTPIKEERNYLHSQDAPTTNALSKKISDI-------LIPASAMKDLKD----------------- 231

  Fly    56 YVDTRSNVSWLKMEKRVRDQRVELHASNNV----------------YVFSFYAKFFPENVSEELI 104
                |.|....:.|:......:.|....||                :::....||..:.|.:.:.
pombe   232 ----RKNALAKEFEESQPGSSLTLKEQANVIDNLRKEVFGLKLKCYFLYDQLNKFHDQEVQDIMK 292

  Fly   105 QEITQHLFFLQVKQS-------ILSMDIYCRPEASVLLAS--------YAVHVQYGP--YDYETY 152
            |.|......::::::       |..::...:|:.|..|::        ..:..:|..  .:.||.
pombe   293 QNIDLKTLTMELQRAVAGYEKKISGLESRIKPDQSFNLSTPSPAPSNLITLQSRYSQALSELETT 357

  Fly   153 KDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEV--EMEYLKIAQDLDMYGVNY 215
            |....|..:  .|.....|.:.....:..:.:..:|:|...::.:  |:|.|::.....:
pombe   358 KRAFAALRK--EKSKKTNYSVGAYNEDRNVLSNMLDNERREKEALLQELESLRVQLSKKV----- 415

  Fly   216 FPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEI--RHVSFDDKKFTIRLV--DAKVSN 276
             |:..||.               |||   ..:|..:.||:  ..:|..::...:|..  |..|..
pombe   416 -PMPAKNT---------------DER---VIETLQRSNELLRMDISMQNEALLLRKQENDRLVKQ 461

  Fly   277 FIFYSQDLHINKM--ILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKE------EKQRRQIE---R 330
            ....:..|:..||  |::.....::|:      |:|.:.:||.|.:.      .||.:.||   .
pombe   462 VEELTVALNSGKMNAIVEAESSKNELW------DSMMVSRMKTQEQSIELTRLYKQLQDIEEDYE 520

  Fly   331 KKFIR-EKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELY---------------- 378
            .|.:| |::.||..:    :|::.:|.:..|::...:.|.:|.:..:.|
pombe   521 NKLMRMEQQWREDVD----QLQEYVEEITQELQDTKEVLSKSSKESDDYEEVVGKLRTEAEREIE 581

  Fly   379 -FEKS-RVNEEQMQLTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDK- 440
             |||: |.|||.:.|.:.:......|:.:|.||......|..:|:|:::       .|..||:|
pombe   582 KFEKTIRENEESISLFKEEVEKLTDEITQLSERYNDKCHEFDELQKRLQ-------TLEEENNKA 639

  Fly   441 -----------------REAETEKLRKELICAKMAEREATARLLEFLNSGRKSSTDSLLTASSVS 488
                             .|||.:.|||        |.|...:::....|....|.|:.|..:...
pombe   640 KEDSTSKTSNLLEQLKMTEAEVDSLRK--------ENEENKQVIALKESELVKSNDNKLLLNEQI 696

  Fly   489 HAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHYLVQ-GDNSSGISDDFEPKEFILTD 552
            .:.|...|.......|:.||..:          |..:.|:...: .|....::......|.||:.
pombe   697 ESLNDQLSQLKTEMESVTTSKES----------LADYLSNLKERHNDELDSLNKKLREFEGILSS 751

  Fly   553 N-----EMEQITNEME--RNHLDYLRNS------KQVQ--------SQLQTLRSEIAPHKIEENQ 596
            |     |:|:..|:..  |.:.|.|:|:      |||.        .|::.|:.|     .:::|
pombe   752 NSSLKSEIEERNNQYVTLRENFDSLQNAIMETFDKQVTHCSVNHLVQQIRKLKDE-----NKKDQ 811

  Fly   597 SNLDIL------SEAQIKAGENKYSTL----KKLKS 622
            |..|.|      .|..:|...|...||    |:||:
pombe   812 SGTDKLMKKIYHCEQSLKEKTNSLETLVSEKKELKN 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	33/236 (14%)
		FERM_C_ERM	210..306	CDD:270015	18/101 (18%)
		ERM	341..635	CDD:395622	75/350 (21%)
mto1	NP_588284.1	Cnn_1N	252..319	CDD:285263	8/66 (12%)
		Fib_alpha	511..611	CDD:285864	23/103 (22%)
		Mto2_bdg	1052..1101	CDD:289572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000