Protein Alignment Mer and Frmd4b

DIOPT Version :9

• Sequence 1: NP_001285458.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_038964692.1
• Gene: Frmd4b / 252858
• RGDID: 620172
• Length: 1066
• Species: Rattus norvegicus
• Alignment Length: 714
• Identity: 171/714 - (23%)
• Similarity: 289/714 - (40%)
• Gaps: 163/714 - (22%)

  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84
            |..||..::|:...::|.|||.....|:|..|||:.::|.....:||:::.||.:.  :|.....
  Rat    68 DRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQENWLQLDHRVLEH--DLPKKPG 130

  Fly    85 VYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPY-- 147
            ..|..|..:|:.|::| .|..:.|..||||..|..:....|....|....||:..:....|.|
  Rat   131 PAVLHFAVRFYIESIS-FLKDKNTVELFFLNAKACVHKGQIEVDSETIFKLAALVLQESKGDYTS 194

  Fly   148 DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDM 210
            |....||     .:.||...|...|..|.:  .|:|:...|:..:.:||.:..::|:||.:.|..
  Rat   195 DENARKD-----LKTLPVFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPT 254

  Fly   211 YGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAK-- 273
            |||:|:.:.:|.....|||::..|:..||.:||:.|:..|||.::.::.|.:|||.:.:.|.:
  Rat   255 YGVHYYAVKDKQGLPWWLGISYKGIGQYDLQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRI 319

  Fly   274 -VSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRRK-----PDTMEIQQMKAQAKEEK 323
             ||...|....|.:.         |.|..:....|..|:.|::     |....:..:.....|..
  Rat   320 SVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDDIAMDLTETG 384

  Fly   324 QRR-----QIERK-KFI-----------------REKKLREKAEHERYELEKSMEHLQNEMRMAN 365
            .:|     .:|.| :||                 .|::.|||.    .||:|..:.||.::
  Rat   385 TQRVSKLVTLEAKSQFIMASNGSLISSGSQDSEGMEEQKREKI----LELKKKEKLLQEKL---- 441

  Fly   366 DALRRSEETKELYFEKS------------RVNEEQMQLTECKANHFKTEMDRLRERQMKIEREKH 418
              |::.||.|::...::            .:.|:..|:.......||.:.:.|...:   :....
  Rat   442 --LKKVEELKKICLREAELTGRMPKEYPLNIGEKPPQVRRRVGTTFKLDDNLLPTEE---DPALQ 501

  Fly   419 DLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAE-REATARLLEFLNS--------GR 474
            :||     ::|.:.|..||..|:.|....|.|.:...:..: .:|..||.|..||        |:
  Rat   502 ELE-----SNFLIQQKLVEAAKKLASEPDLCKTVKKKRKQDYTDAVKRLQEIENSINEYRIRCGK 561

  Fly   475 KSSTDSLLT---------ASSVSHAA-----NTASSMAAISTPSLI------------------- 506
            |.|..:.:.         :||:|...     |.:.::|. ..||.:
  Rat   562 KPSQKAAVVPPEDIIPSESSSLSDTTTYDDPNDSFTLAG-QRPSSVPHSPRILPPKSLGIERIHF 625

  Fly   507 TSSSTND--LETAGGAE-LTTHSSHYLV-----QGDNSSGISDDFEPKEFILTDNEMEQITNEME 563
            ..||.|:  ::|....| |:||||.|..     ||..|.       |...:||       .|...
  Rat   626 RKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSM-------PTTPVLT-------RNAYS 676

  Fly   564 RNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTL-KKLKSGSTK 626
            .:||:...:|:..:.:..:|          |:||:|  |||..   .:..:.|| |..:|.||:
  Rat   677 SSHLEPDSSSQHCRQRSGSL----------ESQSHL--LSEMD---SDKPFFTLSKSQRSSSTE 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	57/199 (29%)
		FERM_C_ERM	210..306	CDD:270015	31/107 (29%)
		ERM	341..635	CDD:395622	77/349 (22%)
Frmd4b	XP_038964692.1	FERM_F1_FRMD4B	57..145	CDD:340720	23/78 (29%)
		B41	75..260	CDD:214604	54/192 (28%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	30/109 (28%)
		DUF3338	395..528	CDD:403120	31/150 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810