DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mer and Frmd4b

DIOPT Version :9

Sequence 1:NP_001285458.1 Gene:Mer / 32979 FlyBaseID:FBgn0086384 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_001333566.1 Gene:Frmd4b / 232288 MGIID:2141794 Length:1035 Species:Mus musculus


Alignment Length:719 Identity:172/719 - (23%)
Similarity:286/719 - (39%) Gaps:173/719 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84
            |..||..::|:...::|.|||.....|:|..|||:.::|.....:||:::.||.:.  :|.....
Mouse    68 DRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQENWLQLDHRVLEH--DLPKKPG 130

  Fly    85 VYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPY-- 147
            ..:..|..:|:.|::| .|..:.|..||||..|..:....|....|....||:..:....|.|  
Mouse   131 PTLLHFAVRFYIESIS-FLKDKNTVELFFLNAKACVHKGQIEVDSETIFKLAALVLQESKGDYTS 194

  Fly   148 DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDM 210
            |....||     .:.||...|...|..|.:  .|:|:...|:..:.:||.:..::|:||.:.|..
Mouse   195 DENARKD-----LKTLPVFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPT 254

  Fly   211 YGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAK-- 273
            |||:|:.:.:|.....|||::..|:..||.:||:.|:..|||.::.::.|.:|||.:.:.|.:  
Mouse   255 YGVHYYAVKDKQGLPWWLGISYKGIGQYDLQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRI 319

  Fly   274 -VSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRR----------------------- 305
             ||...|....|.:.         |.|..:....|..|:.|:                       
Mouse   320 SVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDDIAMDLTETG 384

  Fly   306 -----KPDTMEIQQMKAQA----------------KEEKQRRQIERKKFIREKKLREKAEHERYE 349
                 |..|:|.:.....|                :|:|:.:.:|.||  :||.|:||...:..|
Mouse   385 TQRGSKLVTLEAKSQFIMASNGSLISSGSQDSEGMEEQKREKILELKK--KEKLLQEKLLQKVEE 447

  Fly   350 LEKSMEHLQNEMRMANDALRRSEETKELYFE-KSRVNEEQMQLTECKANHFKTEMDRLRERQMKI 413
            |:|.             .||.:|.|..:..| ...:.|:..|:.......||.:.:.|...:   
Mouse   448 LKKI-------------CLREAELTGRMPKEYPLNIGEKPPQVRRRVGTTFKLDDNLLPTEE--- 496

  Fly   414 EREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAE-REATARLLEFLNS----- 472
            :....:||     ::|.:.|..||..|:.|....|.|.:...:..: .:|..||.|..||     
Mouse   497 DPALQELE-----SNFLIQQKLVEAAKKLASEPDLCKTVKKKRKQDYTDAVKRLQEIENSINEYR 556

  Fly   473 ---GRKSSTDSLLT---------ASSVSHAA-----NTASSMAAISTPSLI-------------- 506
               |:|.|..:.:.         :||:|...     |.:.::|. ..||.:              
Mouse   557 IRCGKKPSQKAAVVPPEDIIPSESSSLSDTTTYDDPNDSFTLAG-QRPSSVPHSPRILPPKSLGI 620

  Fly   507 -----TSSSTND--LETAGGAE-LTTHSSHYLV-----QGDNSSGISDDFEPKEFILTDNEMEQI 558
                 ..||.|:  ::|....| |:||||.|..     ||..|.       |...:||       
Mouse   621 ERIHFRKSSINEQFMDTRHSREMLSTHSSPYKTLERRPQGGRSM-------PTTPVLT------- 671

  Fly   559 TNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTL-KKLKS 622
            .|....:||:...:|:..:.:..:|          |:||:|  |||..   .:..:.|| |..:|
Mouse   672 RNAYSSSHLEPDSSSQHCRQRSGSL----------ESQSHL--LSEMD---SDKPFFTLSKSQRS 721

  Fly   623 GSTK 626
            .||:
Mouse   722 SSTE 725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MerNP_001285458.1 B41 14..216 CDD:214604 56/199 (28%)
FERM_C_ERM 210..306 CDD:270015 31/135 (23%)
ERM 341..635 CDD:395622 76/338 (22%)
Frmd4bNP_001333566.1 Necessary for adherens junction and tight junction localization. /evidence=ECO:0000269|PubMed:20080746 542..972 50/214 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..615 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..699 21/91 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..738 6/13 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..798
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..926
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..958
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 994..1035
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3529
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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