DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mer and FRMD4B

DIOPT Version :9

Sequence 1:NP_001285458.1 Gene:Mer / 32979 FlyBaseID:FBgn0086384 Length:635 Species:Drosophila melanogaster
Sequence 2:XP_016861478.1 Gene:FRMD4B / 23150 HGNCID:24886 Length:1063 Species:Homo sapiens


Alignment Length:729 Identity:173/729 - (23%)
Similarity:292/729 - (40%) Gaps:194/729 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84
            |..||..::|:...::|.|||.....|:|..|||:.::|.....:||:::.||.|.  :|.....
Human    68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDH--DLPKKPG 130

  Fly    85 VYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPY-- 147
            ..:..|..:|:.|::| .|..:.|..||||..|..:....|....|....||::.:....|.|  
Human   131 PTILHFAVRFYIESIS-FLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQEAKGDYTS 194

  Fly   148 DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDM 210
            |....||     .:.||...|...|..|.:  .|:|:...|:..:.:||.:..::|:||.:.|..
Human   195 DENARKD-----LKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPT 254

  Fly   211 YGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAK-- 273
            |||:|:.:.:|.....|||::..|:..||.:||:.|:..|||.::.::.|.:|||.:.:.|.:  
Human   255 YGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRI 319

  Fly   274 -VSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRRK-----PDTMEIQQM-------- 315
             ||...|....|.:.         |.|..:....|..|:.|::     |....:.::        
Human   320 SVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETG 384

  Fly   316 ------------KAQ-------------------AKEEKQRRQIERKKFIREKKLREKAEHERYE 349
                        |:|                   ::|:|:.:.:|.||  :||.|:||       
Human   385 TQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKK--KEKLLQEK------- 440

  Fly   350 LEKSMEHLQNEMRMANDALRRSEETKELYFE------------KSRV------------NEEQMQ 390
            |.|.:|.|:      ...||.:|.|.::..|            :.||            :||...
Human   441 LLKKVEELK------KICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPA 499

  Fly   391 LTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRK----- 450
            |.|.::|....:  :|.|...|:..|. ||.|            ||:..:::..|:.::|     
Human   500 LQELESNFLIQQ--KLVEAAKKLANEP-DLCK------------TVKKKRKQDYTDAMKKLQEIE 549

  Fly   451 ------ELICAKMAEREATARLLEFLNSGRKSSTDSLL-------------TASSVSHAANTASS 496
                  .:.|.|...::||....:.:.|...|.:|:..             .:|||.|      |
Human   550 NAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPH------S 608

  Fly   497 MAAISTPSL------ITSSSTND--LETAGGAE-LTTHSSHYLV-----QGDNSSGISDDFEPKE 547
            ...:...||      ...||.|:  ::|....| |:||||.|..     ||..|.       |..
Human   609 PRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSM-------PTT 666

  Fly   548 FILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGEN 612
            .:||       .|....:||:...:|:..:.:..:|          |:||:|  |||  :.:.:.
Human   667 PVLT-------RNAYSSSHLEPESSSQHCRQRSGSL----------ESQSHL--LSE--MDSDKP 710

  Fly   613 KYSTLKKLKSGSTK 626
            .:|..|..:|.||:
Human   711 FFSLSKSQRSSSTE 724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MerNP_001285458.1 B41 14..216 CDD:214604 57/199 (29%)
FERM_C_ERM 210..306 CDD:270015 31/107 (29%)
ERM 341..635 CDD:395622 77/348 (22%)
FRMD4BXP_016861478.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3529
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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