Protein Alignment Mer and FRMD4B

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_016861478.1
• Gene: FRMD4B / 23150
• HGNCID: 24886
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 173/729 - (23%)
• Similarity: 292/729 - (40%)
• Gaps: 194/729 - (26%)

  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84
            |..||..::|:...::|.|||.....|:|..|||:.::|.....:||:::.||.|.  :|.....
Human    68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDH--DLPKKPG 130

  Fly    85 VYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPY-- 147
            ..:..|..:|:.|::| .|..:.|..||||..|..:....|....|....||::.:....|.|
Human   131 PTILHFAVRFYIESIS-FLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQEAKGDYTS 194

  Fly   148 DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDM 210
            |....||     .:.||...|...|..|.:  .|:|:...|:..:.:||.:..::|:||.:.|..
Human   195 DENARKD-----LKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPT 254

  Fly   211 YGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAK-- 273
            |||:|:.:.:|.....|||::..|:..||.:||:.|:..|||.::.::.|.:|||.:.:.|.:
Human   255 YGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRI 319

  Fly   274 -VSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRRK-----PDTMEIQQM-------- 315
             ||...|....|.:.         |.|..:....|..|:.|::     |....:.::
Human   320 SVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETG 384

  Fly   316 ------------KAQ-------------------AKEEKQRRQIERKKFIREKKLREKAEHERYE 349
                        |:|                   ::|:|:.:.:|.||  :||.|:||
Human   385 TQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKK--KEKLLQEK------- 440

  Fly   350 LEKSMEHLQNEMRMANDALRRSEETKELYFE------------KSRV------------NEEQMQ 390
            |.|.:|.|:      ...||.:|.|.::..|            :.||            :||...
Human   441 LLKKVEELK------KICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPA 499

  Fly   391 LTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRK----- 450
            |.|.::|....:  :|.|...|:..|. ||.|            ||:..:::..|:.::|
Human   500 LQELESNFLIQQ--KLVEAAKKLANEP-DLCK------------TVKKKRKQDYTDAMKKLQEIE 549

  Fly   451 ------ELICAKMAEREATARLLEFLNSGRKSSTDSLL-------------TASSVSHAANTASS 496
                  .:.|.|...::||....:.:.|...|.:|:..             .:|||.|      |
Human   550 NAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPH------S 608

  Fly   497 MAAISTPSL------ITSSSTND--LETAGGAE-LTTHSSHYLV-----QGDNSSGISDDFEPKE 547
            ...:...||      ...||.|:  ::|....| |:||||.|..     ||..|.       |..
Human   609 PRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSM-------PTT 666

  Fly   548 FILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGEN 612
            .:||       .|....:||:...:|:..:.:..:|          |:||:|  |||  :.:.:.
Human   667 PVLT-------RNAYSSSHLEPESSSQHCRQRSGSL----------ESQSHL--LSE--MDSDKP 710

  Fly   613 KYSTLKKLKSGSTK 626
            .:|..|..:|.||:
Human   711 FFSLSKSQRSSSTE 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	57/199 (29%)
		FERM_C_ERM	210..306	CDD:270015	31/107 (29%)
		ERM_helical	340..459	CDD:466641	31/153 (20%)
		ERM_C	559..635	CDD:459932	17/68 (25%)
FRMD4B	XP_016861478.1	FERM_F1_FRMD4B	57..145	CDD:340720	23/78 (29%)
		B41	75..260	CDD:214604	54/192 (28%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	30/109 (28%)
		CUPID	395..529	CDD:463360	35/163 (21%)