Protein Alignment Mer and Ezr

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_033536.2
• Gene: Ezr / 22350
• MGIID: 98931
• Length: 586
• Species: Mus musculus
• Alignment Length: 637
• Identity: 263/637 - (41%)
• Similarity: 379/637 - (59%)
• Gaps: 64/637 - (10%)

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:||||||.|||||||||.:...:|||::|:|..
Mouse     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSA 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|.   ..|...|.|.|||:||:|:|||||:|||.|||||||..|||.:|||.||.:|||.|||
Mouse    68 QEVR---KENPVQFKFRAKFYPEDVAEELIQDITQKLFFLQVKDGILSDEIYCPPETAVLLGSYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..::|.|:.|.:|.|.|:...|:|:.|.||::::.:.||:||:.|:.:|..|.:|...:|||||
Mouse   130 VQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||:|||.|.||..|.|||||.::|||||::.||||||..|.|:|||::||:||||.|:.
Mouse   195 AQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||::..
Mouse   260 IDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||..|.|:.::.:..|.|...::......:|:|  |||    |...|:.:||.| :....
Mouse   325 TEKKRRETVEREKEQMLREKEELMLRLQDYEQKTKRAE--KEL----SEQIEKALQLEE-ERRRA 382

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            :.|.:||...:|...|.|.:||                   |:|:.:...:|.:.|::||..|..
Mouse   383 QEEAERLEADRMAALRAKEELE-------------------RQAQDQIKSQEQLAAELAEYTAKI 428

  Fly   465 RLLEFLNSGR-----------KSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAG 518
            .|||.....:           |.:.|.|:......|...||...........:.......|:..
Mouse   429 ALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDE- 492

  Fly   519 GAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTL 583
            |||...:|:..     :|.||.||         .||.::|| |.|:|        ::||.||.||
Mouse   493 GAEPMGYSAEL-----SSEGILDD---------RNEEKRIT-EAEKN--------ERVQRQLLTL 534

  Fly   584 RSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            .:|::..:.|..:::.||:....::.|.:||.||::::.|:||.|:..||.:
Mouse   535 SNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	108/201 (54%)
		FERM_C_ERM	210..306	CDD:270015	59/95 (62%)
		ERM_helical	340..459	CDD:466641	28/118 (24%)
		ERM_C	559..635	CDD:459932	25/75 (33%)
Ezr	NP_033536.2	B41	7..206	CDD:214604	108/201 (54%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000250|UniProtKB:P15311	115..120		3/4 (75%)
		FERM_C_ERM	200..296	CDD:270015	59/95 (62%)
		Interaction with SCYL3. /evidence=ECO:0000250	244..586		131/391 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..338		17/31 (55%)
		ERM_helical	337..456	CDD:466641	32/144 (22%)
		ERM_C	510..586	CDD:459932	30/93 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..565		6/30 (20%)