Protein Alignment Mer and Frmd4a

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_006497499.1
• Gene: Frmd4a / 209630
• MGIID: 1919850
• Length: 1061
• Species: Mus musculus
• Alignment Length: 723
• Identity: 165/723 - (22%)
• Similarity: 288/723 - (39%)
• Gaps: 147/723 - (20%)

  Fly     3 PFGSKKNRSLS-------VRVSTFDS-ELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDT 59
            |:||.:.||:.       .:|...|. :||..::|:...::|.|||.....|:|..|||:.:.|.
Mouse    19 PYGSLRRRSVERMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDE 83

  Fly    60 RSNVSWLKMEKRVRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMD 124
            ..:::||::::||.:.  :....:...|..|..:|:.|::| .|....|..||||..|..|....
Mouse    84 TGHLNWLQLDRRVLEH--DFPKKSGPVVLYFCVRFYIESIS-YLKDNATIELFFLNAKSCIYKEL 145

  Fly   125 IYCRPEASVLLASYAVHVQYGPY-DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWY 186
            |....|....||||.:....|.: ..|..:..:    :.||...|...:..|.:  .|:|:..:|
Mouse   146 IDVDSEVVFELASYILQEAKGDFSSNEVVRSDL----KKLPALPTQALKEHPSLAYCEDRVIEYY 206

  Fly   187 MDHEPMTRDEVEMEYLKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQ 251
            ......||.:..:.|:.|.:.|..|||:|:.:.:|.....|||::..|:..||..||:.|:..||
Mouse   207 KKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQ 271

  Fly   252 WNEIRHVSFDDKKFTIRLVD---AKVSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRR 304
            |.::.::.|.:|||::.:.|   |.|:...|....:.::         |.|..:....|..|:.|
Mouse   272 WRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDR 336

  Fly   305 RKP-----------------------DTMEIQQMKAQAK--------------EEKQRRQIERKK 332
            ::.                       .|.::..|.::.|              :|....|..:|.
Mouse   337 KQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKD 401

  Fly   333 FIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECK-A 396
            .:...|.|::|      ||:::.....|::..  .||.:|.|.:|..|......|:..:...: .
Mouse   402 MLAALKSRQEA------LEETLRQRLEELKRL--CLREAELTGKLPVEYPLDPGEEPPIVRRRIG 458

  Fly   397 NHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAE----TEKLRKELICAKM 457
            ..||     |.|:::..:.|:.:||:..|  :|.:.....|..:|.|.    ::||:|:   .|.
Mouse   459 TAFK-----LDEQKILPKGEEAELERLER--EFAIQSQITEAARRLASDPNVSKKLKKQ---RKT 513

  Fly   458 AEREATARLLEF---LNSGR-KSSTDSLLTASSVSHAANTASSMAAIS-------TPSLITS--- 508
            :...|..:|.|.   :|..| ||.......||.|....|.||..:::|       ..|.:||
Mouse   514 SYLNALKKLQEIENAINENRIKSGKKPTQRASLVIDDGNIASEDSSLSDALVLEDEDSQVTSTIS 578

  Fly   509 --------------SSTN------DLETAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILT-- 551
                          ||.|      .||  |..:|..|.:.|    |.|     ..:||.:..:
Mouse   579 PLQSPHKGLPPRPPSSHNRPPPPQSLE--GLRQLHYHRTDY----DKS-----PLKPKMWSESSL 632

  Fly   552 DNEMEQITNEMERNHLDYLR--------NSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIK 608
            |...|::.......|....:        ....|.|.||.......||  ..:||::....:.:::
Mouse   633 DEPYEKVKKRSSHGHSSSHKRFPSTGSCTEAGVSSSLQNSPIRSLPH--WNSQSSMPSTPDLRVR 695

  Fly   609 AGENKYST 616
            :....:||
Mouse   696 SPHYVHST 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	55/205 (27%)
		FERM_C_ERM	210..306	CDD:270015	30/107 (28%)
		ERM_helical	340..459	CDD:466641	28/123 (23%)
		ERM_C	559..635	CDD:459932	11/66 (17%)
Frmd4a	XP_006497499.1	FERM_F1_FRMD4B	33..121	CDD:340720	23/89 (26%)
		B41	36..236	CDD:214604	55/206 (27%)
		FERM_C_FRMD4A_FRMD4B	232..342	CDD:270012	29/109 (27%)
		CUPID	371..506	CDD:463360	29/149 (19%)