DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and Rdx

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001098086.1	Gene:	Rdx / 19684	MGIID:	97887	Length:	583	Species:	Mus musculus

Alignment Length:	626	Identity:	269/626 - (42%)
Similarity:	384/626 - (61%)	Gaps:	45/626 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :.::|||:|.|:||||.::|..:|:.|||.|.:|:||||.|:|||||||::...:|||:.|:|..
Mouse     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|:   ..|...|.|.||||||:|||||||||||.|||||||::||:.:|||.||.:|||||||
Mouse    68 QDVK---KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..:||.|:.|.:|.|.||...|||:.|.:|:::|.|.|||||:.|:.:|..|.|::..||||||
Mouse   130 VQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..|:|||||.::|||||:..||||||..|.|:|||::||:||||.|:.
Mouse   195 AQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||.:..
Mouse   260 IDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||.||.|:..:|:..|.|...:|...:...:::  |||        |||.:    ||...
Mouse   325 NEKKKREIAEKEKERIEREKEELMERLRQIEEQTVKAQ--KEL--------EEQTR----KALEL 375

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            :.|..|.:|...:::||:...|    :|...:        .::|..:...:|.:.|::||..|..
Mouse   376 EQERQRAKEEAERLDRERRAAE----EAKSAI--------AKQAADQMKNQEQLAAELAEFTAKI 428

  Fly   465 RLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHY 529
            .|||   ..:|...:.   |:...|.|..|......:...|.|..|.............|.:.|.
Mouse   429 ALLE---EAKKKKEEE---ATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHD 487

  Fly   530 LVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEE 594
             .|.:||:..|.:...:..:...:|.|::| |.::|        ::|:.|||.|.||:|..:.|.
Mouse   488 -EQDENSAEASAELSSEGVMNHRSEEERVT-ETQKN--------ERVKKQLQALSSELAQARDET 542

  Fly   595 NQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            .::..|:|....:|||.:||.||::::.|:||.|:..||.:
Mouse   543 KKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	116/201 (58%)
		FERM_C_ERM	210..306	CDD:270015	60/95 (63%)
		ERM	341..635	CDD:395622	75/293 (26%)
Rdx	NP_001098086.1	B41	7..206	CDD:214604	116/201 (58%)
		Phosphatidylinositol binding	60..63		1/2 (50%)
		FERM_C_ERM	200..296	CDD:270015	60/95 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..333		11/22 (50%)
		ERM	347..583	CDD:307079	69/277 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..407		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..530		21/105 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..555		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810