Protein Alignment Mer and Nf2

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_035028.2
• Gene: Nf2 / 18016
• MGIID: 97307
• Length: 596
• Species: Mus musculus
• Alignment Length: 631
• Identity: 292/631 - (46%)
• Similarity: 409/631 - (64%)
• Gaps: 53/631 - (8%)

  Fly     7 KKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKR 71
            |:.::.:||:.|.|:|:||..|.:..|:|||||||||:||||:|:|||||. .:..|:||||:|:
Mouse    17 KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKK 80

  Fly    72 VRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLA 136
            |.|..|   :......|.|.|||:|||..|||:|||||||||||||:.||...:||.||||||||
Mouse    81 VLDHDV---SKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLA 142

  Fly   137 SYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEY 201
            ||||..:||.||...:|.|.||..|||||.|.:.||||||||||||..||.:|....|||.||||
Mouse   143 SYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207

  Fly   202 LKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFT 266
            |||||||:|||||||.|.||..|:|.|||.::||:|||..::||||.:|.|||||::|:.||:||
Mouse   208 LKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFT 272

  Fly   267 IRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERK 331
            |:.:|.|:..|.|.|..|.:||:||.||.|||||:|||||.|::|:|||||||:|||.|:|:||:
Mouse   273 IKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQ 337

  Fly   332 KFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKA 396
            :..|||::||:||..|.|||:.:..::.|..|||:||.|||||.:|..||:::.||:.:|...||
Mouse   338 RLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 402

  Fly   397 NHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAERE 461
            ...:.||.|::...::.|.||..:|:|:.:|:....::..|:::|..|.::|:::|..|:.|||.
Mouse   403 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERR 467

  Fly   462 ATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHS 526
            |..:|||....                   .|...|..|..|                  |....
Mouse   468 AKQKLLEIATK-------------------PTYPPMNPIPPP------------------LPPDI 495

  Fly   527 SHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHK 591
            ..:.:..|:   :|.||:       |.:|::::.|:|:..::|:..||.:|.||..|::||...|
Mouse   496 PSFDIIADS---LSFDFK-------DTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550

  Fly   592 IEENQSNLDIL-SEAQIKAG-ENKYSTLKKLKSGSTKARVAFFEEL 635
            ::|.::.||:| ||:..:.| .:|::|:|||...|.|:||||||||
Mouse   551 LKERETALDVLHSESSDRGGPSSKHNTIKKLTLQSAKSRVAFFEEL 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	125/201 (62%)
		FERM_C_ERM	210..306	CDD:270015	56/95 (59%)
		ERM_helical	340..459	CDD:466641	42/118 (36%)
		ERM_C	559..635	CDD:459932	32/77 (42%)
Nf2	NP_035028.2	B41	23..222	CDD:214604	125/202 (62%)
		FERM_C_ERM	216..312	CDD:270015	56/95 (59%)
		PLN03086	307..>367	CDD:178635	32/59 (54%)
		ERM_helical	346..465	CDD:466641	42/118 (36%)
		ERM_C	518..596	CDD:459932	32/77 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..580		6/19 (32%)