DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and Msn

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_034963.2	Gene:	Msn / 17698	MGIID:	97167	Length:	577	Species:	Mus musculus

Alignment Length:	632	Identity:	258/632 - (40%)
Similarity:	378/632 - (59%)	Gaps:	63/632 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :::||||:|.|:||||.::|..:|:.|||.|.:||||||.|:|||||.||::..:|||:.|:|..
Mouse     3 KTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKAFSTWLKLNKKVTA 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|.   ..:..:|.|.|||:||:|||||||:|||.|||||||:.||:.||||.||.:|||||||
Mouse    68 QDVR---KESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..:||.::.|.:|.|.|||.:|||:.|.:|:::..:.|||||:.|:.:|..|.|::..:|||||
Mouse   130 VQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..::|||||.::|||||::.|:||||..|.|:|||::||:||||.|:.
Mouse   195 AQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||....
Mouse   260 IDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERALLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||.||.|:.::|:..|.|..:::..      .|:||:...|........::| |.:....
Mouse   325 NEKKKRELAEKEKEKIEREKEELMEKLKQI------EEQTKKAQQELEEQTRRALEL-EQERKRA 382

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464
            ::|.::|.:.:.:.|..|..|.:..||......||..|..:..|...:|       :||.::..:
Mouse   383 QSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLASEMAELTARISQL-------EMARKKKES 440

  Fly   465 RLLEFLNSGRKSSTD------SLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELT 523
            ..:|:....:....|      .|.||.|..|.|..|              .:.:|.:...|||.
Mouse   441 EAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPA--------------ENEHDEQDENGAEA- 490

  Fly   524 THSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIA 588
                        |:.:..|...|     |...|:.|.|.|:|        ::||..|:.|.||:|
Mouse   491 ------------SAELRADAMAK-----DRSEEERTTEAEKN--------ERVQKHLKALTSELA 530

  Fly   589 PHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ..:.|..::..|::....::.|.:||.||::::.|:||.|:..||.:
Mouse   531 NARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	112/201 (56%)
		FERM_C_ERM	210..306	CDD:270015	58/95 (61%)
		ERM	341..635	CDD:395622	69/299 (23%)
Msn	NP_034963.2	B41	7..206	CDD:214604	112/201 (56%)
		FERM_N	9..71	CDD:286467	33/61 (54%)
		FERM_M	91..206	CDD:278785	67/114 (59%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000250\|UniProtKB:P26038	115..120		3/4 (75%)
		FERM_C_ERM	200..296	CDD:270015	58/95 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..342		8/19 (42%)
		ERM	348..577	CDD:279153	62/282 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..419		14/61 (23%)
		TMPIT	383..>464	CDD:285135	16/87 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..518		17/89 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820