Protein Alignment Mer and erm-1

DIOPT Version :9

• Sequence 1: NP_001285458.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_491560.1
• Gene: erm-1 / 172174
• WormBaseID: WBGene00001333
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 633
• Identity: 248/633 - (39%)
• Similarity: 360/633 - (56%)
• Gaps: 84/633 - (13%)

  Fly    12 LSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQR 76
            ::|||::.||||||.::...:|:.|||.|.:||||||.|||||||.|.:...:|||:.|:|..|.
 Worm     7 INVRVTSMDSELEFAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYTDNKGFPTWLKLNKKVLSQD 71

  Fly    77 VELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVH 141
            |:   .:...||.|.|||:||:|:||:||::|..||:||||..|||.:|||.||.||||||||:.
 Worm    72 VK---KDPTLVFKFRAKFYPEDVAEEIIQDVTMRLFYLQVKDGILSDEIYCPPETSVLLASYAMQ 133

  Fly   142 VQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKIAQ 206
            .:||.|..||:..|.|....|||:.|..|:::..|.||.||.||:.||...||::..:|||||||
 Worm   134 AKYGDYVPETHVAGCLTADRLLPQRVLGQFKLNSEEWERRIMTWWADHRATTREQAMLEYLKIAQ 198

  Fly   207 DLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVD 271
            ||:|||||||.|.||..|.|:|||.::||||||:.|:|:||..|.|:|||::||:||||.|:.:|
 Worm   199 DLEMYGVNYFEIRNKKGTDLYLGVDALGLNIYDKADRLSPKVGFPWSEIRNISFNDKKFVIKPID 263

  Fly   272 AKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIRE 336
            .|..:|:||:..|.|||.||.||.|||:||||||||||:|:||||.||:|::..:..|::|..||
 Worm   264 KKAHDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKQQAREDRALKIAEQEKLTRE 328

  Fly   337 KKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEET--------KELYFEKSRVNEEQMQLTE 393
            ...||:||..:.:.||.|..:|.:|..|...|..:..|        |:|...|..:.:::.:|.|
 Worm   329 MSAREEAEQRQRDAEKRMAQMQEDMERARLELAEAHNTIHSLEAQLKQLQLAKQALEQKEYELRE 393

  Fly   394 CKANHFKTEMDRLRERQMKIEREKHDLEKK-IRDADFYVHQLTVENDKREAETEKLRKELICAKM 457
            ..|             |::.|:...|.|:: :||          :.|.||.|...:|:|:
 Worm   394 LTA-------------QLQSEKAMSDGERRHLRD----------QVDAREREVFSMREEV----- 430

  Fly   458 AEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAEL 522
             ||:.|.             |..|.|...........|:...:|.......::|:| |..|..||
 Worm   431 -ERQTTV-------------TRQLQTQIHSQQHTQHYSNSHHVSNGHAHDETATDD-EDNGATEL 480

  Fly   523 TTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEI 587
            |..:...:.|                    :|:|::| ..|:|        .|::::|..|..|:
 Worm   481 TNDADQNVPQ--------------------HELERVT-AAEKN--------IQIKNKLDMLTREL 516

  Fly   588 APHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ...|.:...::.|:|.....|||.:||.||::::.|:||.|:..:|.:
 Worm   517 DSVKDQNAVTDYDVLHMENKKAGRDKYKTLRQIRGGNTKRRIDQYENM 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	108/201 (54%)
		FERM_C_ERM	210..306	CDD:270015	58/95 (61%)
		ERM	341..635	CDD:395622	69/302 (23%)
erm-1	NP_491560.1	B41	9..208	CDD:214604	108/201 (54%)
		FERM_C_ERM	202..298	CDD:270015	58/95 (61%)
		Caldesmon	<302..>362	CDD:366885	23/59 (39%)
		ERM	333..564	CDD:366293	69/302 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920