Protein Alignment Mer and frmd4b

DIOPT Version :9

• Sequence 1: NP_001285458.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_002940561.2
• Gene: frmd4b / 100489171
• XenbaseID: XB-GENE-958639
• Length: 1024
• Species: Xenopus tropicalis
• Alignment Length: 708
• Identity: 167/708 - (23%)
• Similarity: 286/708 - (40%)
• Gaps: 158/708 - (22%)

  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84
            |.|||..::|:...::|.|||.....|:|..|||:.::|.....:||::::||.|.  :....:.
 Frog    68 DRELELLVQPKLLSRELLDLVASHFSLKEKEYFGISFLDDTGQYAWLQLDQRVLDH--DFPKKSG 130

  Fly    85 VYVFSFYAKFFPENVSEELIQEITQ-HLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPY- 147
            .....|..:|:.|:::  .:::||. .||||..|..:....|....|....||:..:....|.|
 Frog   131 PVSLYFVVRFYIESIT--FLKDITTVELFFLNAKACVFKGLIEVDSETIFKLAALILQEARGDYS 193

  Fly   148 -DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWYMDH----EPMTRDEVEMEYLKIA 205
             |....||     .::||...|...|..|.:  .|:|:    ::|    :.:||.:..:.|:||.
 Frog   194 SDENARKD-----LKILPALPTRALQEHPSLSYCEDRV----IEHCKKLKGVTRGQAIVRYMKIV 249

  Fly   206 QDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLV 270
            :.|..|||:|:.:.:|.....|||::..|:..||.:||:.|:..|||.::.::.|.:|||.:.:.
 Frog   250 EALPTYGVHYYKVKDKQGIPWWLGISFKGIGQYDIQDKIKPRKLFQWKQLENLYFREKKFAVEVH 314

  Fly   271 DAK---VSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRRK-----PDTMEIQQMKAQ 318
            |.:   ||...|....|.:.         |.|..:....|..|:.|::     |....:..:..:
 Frog   315 DPRRISVSRRTFGQSSLVVQTWYASNSLIKSIWVMAISQHQFYLDRKQSKAKIPSAKSLDDIAME 379

  Fly   319 AKE---EKQRRQIERKKFI-------------REKKLREKAEHER-YELEKSMEHLQNEMRMAND 366
            ..|   .|..|.:|.|..:             ::.::.|:...|: .||:|..|.|||.:
 Frog   380 LTEAGTTKVARIVEGKNPLIMASSGSLISSGSQDSEISEEQRMEKIQELKKKEEALQNIL----- 439

  Fly   367 ALRRSEETKELYFEKSRVNEEQMQLTECKANHFKTEMDRLRERQ---MKIEREKH--------DL 420
             |::.||.|::...::.:..:..  ||...|..: :...:|.|.   .|:....|        :|
 Frog   440 -LKKIEELKKICLREAELTGKLP--TEYPLNPGE-KPPNVRRRMGATFKLNDILHTDEDPALQEL 500

  Fly   421 EKKIRDADFYVHQLTVENDKREAETEKLRKEL----------ICAKMAEREATARLLEFLNSGRK 475
            |:|     |.:.|..||..|:.|....|.|.:          ...|:.|.|:|  :.||.....|
 Frog   501 ERK-----FLIQQQLVEATKKLATEPDLSKNVKRKRKQDYSDSIKKLQELEST--INEFRVKSGK 558

  Fly   476 SST--------DSLLTA--SSVSHAANTASSMAAI-------STPSL-ITSSSTNDLETAGGAEL 522
            :.|        |.::.:  ||:|.........:.:       ::|:: :|.|...|...|....|
 Frog   559 TPTKRASMILQDDIIPSETSSLSDTTTLEDDESQLPQGQRLHNSPNVHLTKSIGGDKSLARKFSL 623

  Fly   523 --------------TTHSSHYLVQ-----GDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLD 568
                          :||||.|..|     |..|.       |...:||.|....          .
 Frog   624 NEQLSEMRVTREPSSTHSSPYKTQERKPHGGRSM-------PSTPVLTRNAFSS----------S 671

  Fly   569 YLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTK 626
            :|:|....|...|. |..:        :|:..|||:|  ..|...:|..|..:|.||:
 Frog   672 HLQNEGTPQYNRQR-RGSL--------ESHTPILSDA--VDGTPAFSISKSQRSNSTE 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	56/204 (27%)
		FERM_C_ERM	210..306	CDD:270015	31/107 (29%)
		ERM	341..635	CDD:395622	77/345 (22%)
frmd4b	XP_002940561.2	Ubiquitin_like_fold	57..145	CDD:391949	23/78 (29%)
		B41	60..260	CDD:214604	56/204 (27%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	30/109 (28%)
		DUF3338	393..525	CDD:371743	32/145 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910