DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mer and frmd4bb

DIOPT Version :9

Sequence 1:	NP_001285458.1	Gene:	Mer / 32979	FlyBaseID:	FBgn0086384	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_009294836.1	Gene:	frmd4bb / 100329900	ZFINID:	ZDB-GENE-100921-74	Length:	1053	Species:	Danio rerio

Alignment Length:	710	Identity:	170/710 - (23%)
Similarity:	289/710 - (40%)	Gaps:	160/710 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84
            |.:||..::|:...::|.|||.....|:|..|||..|||......||::|:||.:.  :....:.
Zfish    95 DRKLEMLVQPKLLSRELLDLVSSHFNLKEKEYFGFTYVDDTGQCKWLQLERRVLEH--DFSKKSG 157

  Fly    85 VYVFSFYAKFFPENVSEELIQE-ITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPY- 147
            .....|..:|:.|::|  |::| .|..||||..|.:|.:.||....|....||::|:....|.|
Zfish   158 PIALQFLVRFYIESIS--LLKEHTTVELFFLNAKSAIYNGDIEVESELVFKLAAHALQESKGDYT 220

  Fly   148 -DYETYKDGMLAGGELLPKGVTDQYQMTPEM--WEERIKTWYMDHEPMTRDEVEMEYLKIAQDLD 209
             |..|..|  |....:||..|..::   |.:  .|||:...|...:.::|.:..::|:.:.|.|.
Zfish   221 SDENTRAD--LKKFPVLPTKVLKEH---PSLAYCEERVMEQYRLLKGISRGQAIVQYMTLVQSLP 280

  Fly   210 MYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVD--- 271
            .|||:|:.:.:|.....|||::..|:..||.:||:.|:..|||.::.::.|.:|||.:.:.|
Zfish   281 TYGVHYYEVKDKQGMPWWLGISYKGIGQYDHQDKVKPRKLFQWKQLENLYFREKKFAVEVNDPHR 345

  Fly   272 AKVSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQ 327
            ..|:...|....|.|:         |.|..:....|..|:.|:        |.||
Zfish   346 RAVTKRTFGQTGLVIHTWYATHSLIKTIWVMAISQHQFYLNRK--------QSKA---------- 392

  Fly   328 IERKKFIREKKLREKA----EHERYELEKSMEHLQNEMRMAN----------DALRRSEETKELY 378
                |....:.|.:.|    |:...::.|....::|::.||:          |:....|:.||..
Zfish   393 ----KITTARSLGDIAVDLTENGASKMSKLSAGVKNQLIMASNGSLVSTGSADSEMNDEQKKEKL 453

  Fly   379 FEKSRVNEEQMQ------LTECKANHFKTEMDRLRERQM--KIERE------------------- 416
            .| .|..|..:|      |||.|      |: .|||.::  |:.:|
Zfish   454 AE-LRKKERDIQDILSQKLTELK------EI-CLREAELTGKLPKEYPLIKGETPPHVRRRVGTA 510

  Fly   417 --------------------KHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAERE 461
                                :..|::||.:|   ..:|..|.|..:...:|.|:..:.|....:|
Zfish   511 FKLDDLFPYNEDPYLRNLESRFALQQKIVEA---AKKLAAEPDISKLVRKKRRRNCLDAMQKLQE 572

  Fly   462 ATARLLEF-LNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTH 525
            ....:.:: |..|:|.:.    .||.:     .|..:|.....||..|...:|.:  ||....:.
Zfish   573 IEDEMNQYRLKKGQKPTQ----RASVI-----IADELAQSECSSLCDSLPLDDDD--GGQRPRSR 626

  Fly   526 S---SHYLVQGDNSSGISDDFEPKEFILT-----DNEMEQITNEM-ERNHLDYLRNSKQVQSQ-L 580
            |   |..|....:|||:  ||:|:....:     |..:.::.:|: |..|....|.....||. .
Zfish   627 SVQCSPCLSPPLSSSGL--DFDPERRSSSSDTHHDRPLNRLDHEVQEPGHYYTPREVFSAQSSPC 689

  Fly   581 QTL-RSEIAPHKIEEN-------QSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFF 632
            :|| |....|..:.:.       .|:..:.|:..|:|..:        :|||.:::...|
Zfish   690 KTLSRMPKDPRSLPQTPVLPRNAYSSSQLRSDGHIRAFRH--------RSGSLESQSQLF 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_001285458.1	B41	14..216	CDD:214604	61/200 (31%)
		FERM_C_ERM	210..306	CDD:270015	31/107 (29%)
		ERM	341..635	CDD:395622	76/372 (20%)
frmd4bb	XP_009294836.1	B41	88..287	CDD:214604	61/200 (31%)
		FERM_N	90..151	CDD:286467	21/57 (37%)
		FERM_M	173..287	CDD:278785	37/120 (31%)
		FERM_C_FRMD4A_FRMD4B	283..393	CDD:270012	33/131 (25%)
		DUF3338	427..553	CDD:288652	27/136 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900