Protein Alignment Mer and msn

DIOPT Version :10

• Sequence 1: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_002936828.1
• Gene: msn / 100145669
• XenbaseID: XB-GENE-1004600
• Length: 580
• Species: Xenopus tropicalis
• Alignment Length: 643
• Identity: 261/643 - (40%)
• Similarity: 378/643 - (58%)
• Gaps: 82/643 - (12%)

  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74
            :::||||:|.|:||||.::|..:|:.|||.|.:||||||.|:|||||.||:...:|||:.|:|..
 Frog     3 KTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTA 67

  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139
            |.|.   .::..:|.|.|||:||:|||||||:|||.|||||||:.||:.||||.||.:|||||||
 Frog    68 QDVR---KDSPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYA 129

  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204
            |..:||.|:.|..|.|.|:|.:|||:.|.:|::::.:.|||||..|:.:|..|.|::..:|||||
 Frog   130 VQAKYGDYNKECQKPGYLSGDKLLPQRVLEQHKLSKDQWEERIHVWHEEHRGMLREDAILEYLKI 194

  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269
            ||||:|||||||.|.||..::|||||.::|||||::.|:||||..|.|:|||::||:||||.|:.
 Frog   195 AQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKP 259

  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||....
 Frog   260 IDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERALLE 324

  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399
            .|||.||.||.|:.::|:..|.|...:|...|..|:::|..|   |::|           ||...
 Frog   325 NEKKKRELAEKEKEKIEREKEELMERLRQIEDQTRKAQEALE---EQTR-----------KALEL 375

  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDK----REAETEKLRKELICAKMAER 460
            :.|..|.:|...|:.||:                |..|..|    ::::.:...:|.:.|:::..
 Frog   376 EDERRRAQEEAEKLARER----------------LAAEEAKEALLKQSQDQMKNQEHLAAELSAL 424

  Fly   461 EATARLLEFLNSGRKSSTDSLLTASSVSHAANTASS------------MAAISTPSLITSSSTND 513
            .||...|||....::      |.|......|:...:            |.....|..:.:.:.:|
 Frog   425 TATISQLEFARQKKE------LEAQEWQDKAHNVQADLEKTQEELKLVMTTPHVPEPVHAENEHD 483

  Fly   514 LETAGGAELTTHSSHYLVQGDNSSGISDDFEPK-EFILTDNEMEQITNEMERNHLDYLRNSKQVQ 577
            .|                  ||.:......|.| |.::.|...|..|.|.|:|        ::||
 Frog   484 DE------------------DNENNAEASAELKSEAMIKDRSEEDRTTEAEKN--------ERVQ 522

  Fly   578 SQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635
            ..|..|.||:|..:.|..::..|:|....::||.:||.||::::.|:||.|:..||.:
 Frog   523 KHLLLLSSELANARDETKKTANDLLHAENVRAGRDKYKTLRQIRQGNTKQRIDEFESM 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mer	NP_523413.1	B41	14..216	CDD:214604	112/201 (56%)
		FERM_C_ERM	210..306	CDD:270015	58/95 (61%)
		ERM_helical	340..459	CDD:466641	28/122 (23%)
		ERM_C	559..635	CDD:459932	26/75 (35%)
msn	XP_002936828.1	B41	7..206	CDD:214604	112/201 (56%)
		FERM_C_ERM	200..296	CDD:270015	58/95 (61%)
		ERM_helical	347..456	CDD:466641	29/144 (20%)
		ERM_C	505..580	CDD:459932	28/82 (34%)