DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14227 and TMPRSS11F

DIOPT Version :10

Sequence 1:NP_608345.2 Gene:CG14227 / 32978 FlyBaseID:FBgn0031058 Length:286 Species:Drosophila melanogaster
Sequence 2:NP_997290.2 Gene:TMPRSS11F / 389208 HGNCID:29994 Length:438 Species:Homo sapiens


Alignment Length:277 Identity:75/277 - (27%)
Similarity:125/277 - (45%) Gaps:50/277 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 LLDAECG-RSLPTNAKLTWWNYFDSSTD--IQAN--------PWIVSV-IVNGKAKCSGSLINHR 78
            ||::.|| |...:|..|.    ..|||.  :|..        ||..|: ::....:|..|||::.
Human   181 LLNSRCGIRMTSSNMPLP----ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNT 241

  Fly    79 FVLTAAHCVFREAMQVHLGDFDAWNPGQNCSSGARLSNAYCVR-IDKKIVHAGFGKIQAQQYDIG 142
            ::||||||.::..      |...|    ..:.||.::.....| :.|.|:|..:.: :..:.||.
Human   242 WLLTAAHCFWKNK------DPTQW----IATFGATITPPAVKRNVRKIILHENYHR-ETNENDIA 295

  Fly   143 LLRMQHAVQYSDFVRPICLLINEPVAAI-----DRFQLTVWGTTAEDFRSIPRVLKHSVGDRIDR 202
            |:::...|::|:.|:.:||    |.::|     ....:|.:|:..:| ..|...|:.:..:.|..
Human   296 LVQLSTGVEFSNIVQRVCL----PDSSIKLPPKTSVFVTGFGSIVDD-GPIQNTLRQARVETIST 355

  Fly   203 ELCTLK--FQQQVDESQICVHTETS--HACKGDSGGPFSAKILYGGTYRTFQFGIIIFGLSSCA- 262
            ::|..|  :...:....:|......  .|||||||||    ::|......:..||:.:| .||| 
Human   356 DVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGP----LVYDNHDIWYIVGIVSWG-QSCAL 415

  Fly   263 --GLSVCTNVTFYMDWI 277
              ...|.|.||.|.|||
Human   416 PKKPGVYTRVTKYRDWI 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14227NP_608345.2 Tryp_SPc 57..277 CDD:214473 62/233 (27%)
TMPRSS11FNP_997290.2 SEA 59..158 CDD:460188
Tryp_SPc 206..435 CDD:238113 65/248 (26%)
Blue background indicates that the domain is not in the aligned region.

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