DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14227 and PRSS54

DIOPT Version :9

Sequence 1:	NP_608345.2	Gene:	CG14227 / 32978	FlyBaseID:	FBgn0031058	Length:	286	Species:	Drosophila melanogaster
Sequence 2:	NP_001073961.1	Gene:	PRSS54 / 221191	HGNCID:	26336	Length:	395	Species:	Homo sapiens

Alignment Length:	318	Identity:	69/318 - (21%)
Similarity:	127/318 - (39%)	Gaps:	75/318 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKVIAALL-ILFASLFLGSREGSAFL-LDAECGRSLPTNAKLTWWNYFDSSTDIQANPWIVSVI 63
            |:.|:..|| :|::|...|.::.|.|. .|.:.|              ..||.:.   ||:||:.
Human    13 MRGVLLVLLGLLYSSTSCGVQKASVFYGPDPKEG--------------LVSSMEF---PWVVSLQ 60

  Fly    64 VNGKAKCS-GSLINHRFVLTAAHCVFREAMQVHLGDFDAWNPGQNCSSGARLSNAYCVRIDKKIV 127
            .:.....: |.:::..:||:.|..:......|.:......:|.:...:.        ..::..|:
Human    61 DSQYTHLAFGCILSEFWVLSIASAIQNRKDIVVIVGISNMDPSKIAHTE--------YPVNTIII 117

  Fly   128 HAGFGKIQAQQYDIGLLRMQHAVQYSDFVRPICLL---INEPVAAIDRFQLTVWGTTAEDFRSIP 189
            |..|.. .:...:|.||:...|:.:.:.|:.||.|   ::.| ..:....::.|..|:    :..
Human   118 HEDFDN-NSMSNNIALLKTDTAMHFGNLVQSICFLGRMLHTP-PVLQNCWVSGWNPTS----ATG 176

  Fly   190 RVLKHSVGDRI---DRELCTLKFQQQVDESQICVHT--ETSHACKGDSGGPFSAKILYGGTYRTF 249
            ..:..||..:|   |.::|.|   .::.:::...||  ||..||.||.|.|...::.
Human   177 NHMTMSVLRKIFVKDLDMCPL---YKLQKTECGSHTKEETKTACLGDPGSPMMCQLQ-------- 230

  Fly   250 QF------GIIIFGLSSCAGLSVCTNVTFYMDWI----------------WDALVNLS 285
            ||      |::.||..:|.||.:.|.|..|..||                |:.|::.|
Human   231 QFDLWVLRGVLNFGGETCPGLFLYTKVEDYSKWITSKAERAGPPLSSLHHWEKLISFS 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14227	NP_608345.2	Tryp_SPc	57..277	CDD:214473	51/234 (22%)
CG14227	NP_608345.2	Tryp_SPc	57..277	CDD:238113	51/234 (22%)
PRSS54	NP_001073961.1	Tryp_SPc	52..264	CDD:214473	51/239 (21%)
		Tryp_SPc	52..264	CDD:238113	51/239 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910