DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubqn and ZFAND4

DIOPT Version :9

Sequence 1:	NP_001285457.1	Gene:	Ubqn / 32977	FlyBaseID:	FBgn0031057	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_016872420.1	Gene:	ZFAND4 / 93550	HGNCID:	23504	Length:	741	Species:	Homo sapiens

Alignment Length:	570	Identity:	103/570 - (18%)
Similarity:	186/570 - (32%)	Gaps:	158/570 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SKRINVVVKTPKDKKTV-----EVDE------------------DSGIK-DFKILVAQKFEAEPE 46
            |.|:.|..||...|:..     |.|:                  ||..| ||.:.|.::......
Human   133 SSRVEVWEKTSCSKQVTFLVYQEGDQLNFFPAVDRGDGTLTPLSDSSKKIDFHLHVLRRKGEHRM 197

  Fly    47 QLVLIFAGKIMKDTDTLQ----------MHNIKDNLTVH--LVIKAPTRN---NEQPARQPADVR 96
            ....:.:|..|.::||.:          ...|::::|::  .::||..:|   :::| ::...::
Human   198 SYCFLCSGGSMYNSDTDEDEETEPSSSGQQIIENSITMNKMKLLKAKMKNMNLSKKP-KKAVKIK 261

  Fly    97 QTPFGLNQFGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNN--PDTMR 159
            ..|       .:|...:.|:.:.:    :.|:...|.|.|........|....::..|  .....
Human   262 PHP-------PVAPRPSSGSTAPS----RHRLLRVLPNIGQSCSPAFGNAYPPEISRNGISSLAT 315

  Fly   160 QL--------ITSNPQMHDLMQRNPEISHMLNNPDLLRQT--MELARNPSMLQELM-------RS 207
            ||        ||......|....|..:||..:|..|..|.  :||..:..:...::       |.
Human   316 QLSAERYISSITGEFLKEDNSWENNTLSHFSSNVKLPPQIPHLELGNDQELADSVLHLGSSLPRQ 380

  Fly   208 HDRAMSNLESVPGGYSALQRIYRDIQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRN 272
            ....:.||.|..|          :|..|.....||. ...|..|.:.....|..:....|.|
Human   381 TKHFLGNLPSSNG----------NIVLPSEECVTEQ-SLLPKVGSLASFAEGNADEQSSGLE--- 431

  Fly   273 PLPNPWGGANSG-----TNGTVGGSG--------AGNPTGDLPPNNVLN----TPAMRSLLQQMA 320
                  |.....     ||...|...        ||...|:....:|||    :|....||..:.
Human   432 ------GACKVNLELLLTNADKGLKAPEQHLKHVAGVLNGESVETSVLNYRELSPHKNRLLSPLR 490

  Fly   321 DNPAM------------------------------MQNLLNAPYTRS------MMESMSQDPDMA 349
            .:..|                              :||:.::.::|:      .::|:.:..|:.
Human   491 CSAPMSLHNSLVKPERQSKCFEFGKLQPSSSQSLDVQNITDSSFSRTTCFQGVKVDSLGKRSDVI 555

  Fly   350 ARLLSSSPLMSNNPALQEQVRQMMP-QFMAQMQNPEVMNMLTNPDAMNAILQIQQGM-------- 405
            :::.:.......|.|.:|.|..:.. .|:|.:......|.|.:......:.....|:
Human   556 SKVEARDITEMTNKASKEPVGCVNNISFLASLAGSTSRNRLQSTRGAGRLQNSGTGLSTNLQHFQ 620

  Fly   406 -EQLRSAAPGLVGTLGIPPPPPGAG-TGTNPASGDGSGGNSGASTNNVSP 453
             |..|.::|.|..| |:.....|.| .|.|.|:|...|   ..:|:::.|
Human   621 EENFRKSSPQLEHT-GVFLSTHGVGMNGNNAAAGKSVG---ECTTHHLPP 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	18/105 (17%)
		hPLIC_N	9..79	CDD:176403	18/105 (17%)
		STI1	322..368	CDD:128966	8/81 (10%)
		UBA_PLICs	501..537	CDD:270582
ZFAND4	XP_016872420.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900