DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubqn and UBQLN4

DIOPT Version :9

Sequence 1:	NP_001285457.1	Gene:	Ubqn / 32977	FlyBaseID:	FBgn0031057	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_064516.2	Gene:	UBQLN4 / 56893	HGNCID:	1237	Length:	601	Species:	Homo sapiens

Alignment Length:	619	Identity:	289/619 - (46%)
Similarity:	389/619 - (62%)	Gaps:	92/619 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAE--GGSKR--INVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTD 61
            |||  |...|  |.|.|||||||:.:.:.:.:.:|:||..::::|:|:.:||||||||||:||.|
Human     1 MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGD 65

  Fly    62 TLQMHNIKDNLTVHLVIKAPTR------------NNEQPARQPADVRQTPFG------------- 101
            ||..|.|||.||||||||.|.:            :...||..|:....:|..
Human    66 TLNQHGIKDGLTVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSD 130

  Fly   102 ----------------------------LNQFGGLAGMEALGAGSNTFMDLQARMQNELLNNGDM 138
                                        |:.|||:.|:.:||.||..||:||.:||.:|::|.:|
Human   131 AGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEM 195

  Fly   139 LRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQE 203
            |..:|:||:||.||:|||.||.:|.:||||..||:||||||||||||:|:||||||||||:|:||
Human   196 LSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQE 260

  Fly   204 LMRSHDRAMSNLESVPGGYSALQRIYRDIQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGT 268
            :||:.|||:|||||:||||:||:|:|.||||||.:||.|.||.|||:.|  .|.|.:.::....|
Human   261 MMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSL--AGNSDSSSSQPLRT 323

  Fly   269 ENRNPLPNPWG-------GANSGTNGTVGGSGAG--NPTGDLP--------PNNVLNTPAMRSLL 316
            |||.||||||.       ...||..|| ||||..  :||...|        .:.:.|:|.|::||
Human   324 ENREPLPNPWSPSPPTSQAPGSGGEGT-GGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALL 387

  Fly   317 QQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAARLLSSSPLMSNNPALQEQVRQMMPQFMAQMQ 381
            ||:::||.:|||:::|||.||||::::|:||.||:::.:.||.:.||.||||:|..:|.|:.|||
Human   388 QQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQ 452

  Fly   382 NPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSGA 446
            |||.:::||||.||.|:||||||::.|::.|||||.:||      ..|....||.   |.|::..
Human   453 NPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLG------SFGISRTPAP---SAGSNAG 508

  Fly   447 STNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSNNADNTQPPEVRYQSQLEQLNA 511
            ||.....||.....|.:|.   |.....|.....|:::|.|..|:  ..|.||||:|.||||||:
Human   509 STPEAPTSSPATPATSSPT---GASSAQQQLMQQMIQLLAGSGNS--QVQTPEVRFQQQLEQLNS 568

  Fly   512 MGFVNRDANLQALIATFGDINAAVERLLSLNQLS 545
            |||:||:|||||||||.||||||:||||. :|||
Human   569 MGFINREANLQALIATGGDINAAIERLLG-SQLS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	39/69 (57%)
		hPLIC_N	9..79	CDD:176403	39/69 (57%)
		STI1	322..368	CDD:128966	23/45 (51%)
		UBA_PLICs	501..537	CDD:270582	28/35 (80%)
UBQLN4	NP_064516.2	UBQ	13..83	CDD:214563	39/69 (57%)
		hPLIC_N	13..83	CDD:176403	39/69 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..155		4/67 (6%)
		STI1	192..229	CDD:128966	20/36 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..366		28/67 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..533		14/54 (26%)
		UBA_PLICs	558..597	CDD:270582	31/38 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	407	1.000	Domainoid score	I703
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1196
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54270
OrthoDB	1	1.010	-	-		D1553668at2759
OrthoFinder	1	1.000	-	-		FOG0001496
OrthoInspector	1	1.000	-	-		otm40720
orthoMCL	1	0.900	-	-		OOG6_100933
Panther	1	1.100	-	-	LDO	PTHR10677
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2096
SonicParanoid	1	1.000	-	-		X761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870