DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubqn and UBQLN3

DIOPT Version :9

Sequence 1:	NP_001285457.1	Gene:	Ubqn / 32977	FlyBaseID:	FBgn0031057	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001334025.1	Gene:	UBQLN3 / 50613	HGNCID:	12510	Length:	655	Species:	Homo sapiens

Alignment Length:	684	Identity:	223/684 - (32%)
Similarity:	314/684 - (45%)	Gaps:	178/684 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEGGS-------------KRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIF 52
            ||:||.             ..|.|.|||||||:...|.:...|:..|..::|:|:|.|:||||||
Human     1 MAKGGEALPQGSPAPVQDPHLIKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRFKAHPDQLVLIF 65

  Fly    53 AGKIMKDTDTLQMHNIKDNLTVHLVIKAPTR--NNEQPARQPADVRQTPFGLNQ----------- 104
            ||||:||.|:|....::|.||||||||...|  .||.||........:|..|.|
Human    66 AGKILKDPDSLAQCGVRDGLTVHLVIKRQHRAMGNECPAASVPTQGPSPGSLPQPSSIYPADGPP 130

  Fly   105 ---FGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNP 166
               .|.|.|:..||.....|.|..:.:..:.::..:.:..|:|:|.:..:::|...:|||:..||
Human   131 AFSLGLLTGLSRLGLAYRGFPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNP 195

  Fly   167 QMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRD 231
            .|..|:|.||||.|:||||:::|||:|..|||:|:||::||.||.:|||||:||||:.|..:|.|
Human   196 HMQQLIQHNPEIGHILNNPEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTD 260

  Fly   232 IQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPWGGANSGTNGTVGGSGA-- 294
            |.:||:||..|.||.||||.......:...:.|.: .||.:||||||       ..|.||||:
Human   261 IMDPMLNAVQEQFGGNPFATATTDNATTTTSQPSR-MENCDPLPNPW-------TSTHGGSGSRQ 317

  Fly   295 GNPTGDL-PPN------NVLNTPAMRSLLQQMADNP------------AMMQN------------ 328
            |...||. .|:      |.|....:...|||:.:||            |:.|:
Human   318 GRQDGDQDAPDIRNRFPNFLGIIRLYDYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRVPP 382

  Fly   329 -----------------------------LLNAPYTRSMMESMSQD-------------PDMAAR 351
                                         .|..|...|..:...||             ||:.:.
Human   383 SSPSSQEPGSGQPLPEESVAIKGRSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDLVSG 447

  Fly   352 L-----------LSSSPL-------------------------MSNNPALQEQVRQMMPQFMAQM 380
            |           ||.||.                         |:..|.||::::..:|..|
Human   448 LGDSANRVPFAPLSFSPTAAIPGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPLLM--- 509

  Fly   381 QNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSG 445
               .:...:.||.|:.|:.||:||::.|.:.||.|:    :...|..||||:      .:||..
Human   510 ---HLQAAMANPRALQALRQIEQGLQVLATEAPRLL----LWFMPCLAGTGS------VAGGIE- 560

  Fly   446 ASTNNVSPSSGLNAGTGTPNLAPGGGP---NAQL--FNDFMMRMLNGM-SNNADNTQPPEVRYQS 504
                  |....|.:....||..|...|   :|:|  .:...:.||..: |.|....| ||..:|.
Human   561 ------SREDPLMSEDPLPNPPPEVFPALDSAELGFLSPPFLHMLQDLVSTNPQQLQ-PEAHFQV 618

  Fly   505 QLEQLNAMGFVNRDANLQALIATFGDINAAVERL 538
            |||||.:|||:||:|||||||||.||::||||:|
Human   619 QLEQLRSMGFLNREANLQALIATGGDVDAAVEKL 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	37/69 (54%)
		hPLIC_N	9..79	CDD:176403	37/69 (54%)
		STI1	322..368	CDD:128966	20/147 (14%)
		UBA_PLICs	501..537	CDD:270582	25/35 (71%)
UBQLN3	NP_001334025.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..124		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..330		21/60 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..399		2/34 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..447		7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8158
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1553668at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880