DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubqn and Ubqln4

DIOPT Version :9

Sequence 1:	NP_001285457.1	Gene:	Ubqn / 32977	FlyBaseID:	FBgn0031057	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001101158.1	Gene:	Ubqln4 / 310633	RGDID:	1308273	Length:	595	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	293/615 - (47%)
Similarity:	394/615 - (64%)	Gaps:	90/615 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAE--GGSKR--INVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTD 61
            |||  |...|  |.|.|||||||:.:.:.:.:.:|:||..::::|:|:.:||||||||||:||.|
  Rat     1 MAEPSGAETRPQIRVTVKTPKDKEEILICDQASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGD 65

  Fly    62 TLQMHNIKDNLTVHLVIKAPTRNNE--------------------QPARQPADVRQTPFG----- 101
            ||..|.|||.||||||||.|.:..:                    .||...|.|:....|
  Rat    66 TLNQHGIKDGLTVHLVIKTPQKAQDPVTTTASSPSTPDSASAPSTTPASPAAPVQPCSSGNTTSD 130

  Fly   102 ----------------------LNQFGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMD 144
                                  |:.|||:.|:.:||.||..||:||.:||.:|::|.:||..:|:
  Rat   131 ASSGGGPSPVAAEGPSNATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIME 195

  Fly   145 NPMVQQMMNNPDTMRQLITSNPQMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHD 209
            ||:||.||:|||.||.:|.:||||..||:||||||||||||:|:||||||||||:|:||:||:.|
  Rat   196 NPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQD 260

  Fly   210 RAMSNLESVPGGYSALQRIYRDIQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPL 274
            ||:||||||||||:||:|:|.||||||..||.|.||.|||:.|. |....:.:.|.: ||||.||
  Rat   261 RALSNLESVPGGYNALRRMYTDIQEPMFTAAREQFGNNPFSSLA-GNSDNSSSQPLR-TENREPL 323

  Fly   275 PNPWG-------GANSGTNGTVGGSGAG--NPTGDLP--------PNNVLNTPAMRSLLQQMADN 322
            ||||.       ...||..|| ||||..  :||...|        .:.:.|:|.|::||||:::|
  Rat   324 PNPWSPSPPTSQAPGSGGEGT-GGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISEN 387

  Fly   323 PAMMQNLLNAPYTRSMMESMSQDPDMAARLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMN 387
            |.:|||:::|||.|:||::::|:||.||:::.:.||.:.||.||||:|..:|.|:.||||||.::
  Rat   388 PQLMQNVISAPYMRTMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLS 452

  Fly   388 MLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSGASTNNVS 452
            :||||.||.|:||||||::.|::.|||||.:||        ..||...|...:|.|||::..  :
  Rat   453 ILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLG--------SFGTPRTSVPLAGSNSGSAAE--A 507

  Fly   453 PSSGLNAGTGTP-NLAPGGGPNAQLFNDFMMRMLNGMSNNADNTQP-PEVRYQSQLEQLNAMGFV 515
            |:    |..||| ...|..|.|.|  ...|.:|:..:|.:.::..| ||||:|.||||||:||||
  Rat   508 PT----ASPGTPATTPPSAGSNTQ--QQLMQQMIQLLSGSGNSQVPVPEVRFQQQLEQLNSMGFV 566

  Fly   516 NRDANLQALIATFGDINAAVERLLSLNQLS 545
            ||:|||||||||.||||||:||||. :|||
  Rat   567 NREANLQALIATGGDINAAIERLLG-SQLS 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	39/69 (57%)
		hPLIC_N	9..79	CDD:176403	39/69 (57%)
		STI1	322..368	CDD:128966	22/45 (49%)
		UBA_PLICs	501..537	CDD:270582	29/35 (83%)
Ubqln4	NP_001101158.1	UBQ	13..83	CDD:214563	39/69 (57%)
		hPLIC_N	13..83	CDD:176403	39/69 (57%)
		STI1	186..223	CDD:128966	20/36 (56%)
		UBA_PLICs	552..591	CDD:270582	32/38 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	390	1.000	Domainoid score	I756
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1225
OMA	1	1.010	-	-		QHG54270
OrthoDB	1	1.010	-	-		D1553668at2759
OrthoFinder	1	1.000	-	-		FOG0001496
OrthoInspector	1	1.000	-	-		otm44857
orthoMCL	1	0.900	-	-		OOG6_100933
Panther	1	1.100	-	-	LDO	PTHR10677
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X761
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840